P43761

PR
Gene name
trpE (HI_1387)
Protein name
Anthranilate synthase component 1
Names
AS, ASI
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_1387
EC number
4.1.3.27: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-266 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43761

Entry ID Method Resolution Chain Position Source
AF-P43761-F1 Predicted AlphaFoldDB

No variants for P43761

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43761

No associated diseases with P43761

2 regional properties for P43761

Type Name Position InterPro Accession
domain Anthranilate synthase component I, N-terminal 54 - 196 IPR006805
domain Chorismate-utilising enzyme, C-terminal 243 - 502 IPR015890

Functions

Description
EC Number 4.1.3.27 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIQTQAFIA VTAQPIPYYA DTTAIFNTLC QSNSNSLLLD SAEIGSKNSL QSLILVNAAV
70 80 90 100 110 120
KITCLGHNVT FKALNNNGKQ VLKEIHPKLT ALGKVSAVNF EDEFSVQFLP LDNQLDEDSK
130 140 150 160 170 180
LQSATIFDGL RVISSLYQHS QTPIFLGGLF AYDLVANFIP MDGITLKNDG INCPDYSFYL
190 200 210 220 230 240
AEHLITIDHQ NQQATLKSFC FAQEEQVNIA KTSLSIAQKL KNIDHVLSIK AASDEVKTNF
250 260 270 280 290 300
DDPEFTGIVK ALKHHINIGD VFQIVPSRRF SLACPNTLAS YAQLKQNNPS PYMFYMNDED
310 320 330 340 350 360
FILFGASPES ALKYAPENRQ LEIYPIAGSR PRGFDAHGNI DPELDARLEL ELRLDHKEQA
370 380 390 400 410 420
EHLMLVDLAR NDIARVCQSG TRKVAELMQV DRYSHIMHLV SRVVGKLRPE LDALHAYQAC
430 440 450 460 470 480
MNMGTLTGAP KIKAMQLIYQ FEQQKRHSYG GAVGYLTSDG HFDTCIVIRS AFVQNGMAHV
490 500 510
QAGCGEVLDS DPQMEADETR HKAAAVLKAI RQVNTQAK