P43744

PR
Gene name
dnaN (HI_0992)
Protein name
Beta sliding clamp
Names
Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0992
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43744

Entry ID Method Resolution Chain Position Source
AF-P43744-F1 Predicted AlphaFoldDB

No variants for P43744

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43744

No associated diseases with P43744

3 regional properties for P43744

Type Name Position InterPro Accession
domain DNA polymerase III, beta sliding clamp, N-terminal 1 - 119 IPR022634
domain DNA polymerase III, beta sliding clamp, C-terminal 245 - 365 IPR022635
domain DNA polymerase III, beta sliding clamp, central 129 - 243 IPR022637

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA polymerase III complex The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA strand elongation involved in DNA replication The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQFSISRENL LKPLQQVCGV LSNRPNIPVL NNVLLQIEDY RLTITGTDLE VELSSQTQLS
70 80 90 100 110 120
SSSENGTFTI PAKKFLDICR TLSDDSEITV TFEQDRALVQ SGRSRFTLAT QPAEEYPNLT
130 140 150 160 170 180
DWQSEVDFEL PQNTLRRLIE ATQFSMANQD ARYFLNGMKF ETEGNLLRTV ATDGHRLAVC
190 200 210 220 230 240
TISLEQELQN HSVILPRKGV LELVRLLETN DEPARLQIGT NNLRVHLKNT VFTSKLIDGR
250 260 270 280 290 300
FPDYRRVLPR NATKIVEGNW EMLKQAFARA SILSNERARS VRLSLKENQL KITASNTEHE
310 320 330 340 350 360
EAEEIVDVNY NGEELEVGFN VTYILDVLNA LKCNQVRMCL TDAFSSCLIE NCEDSSCEYV
IMPMRL