P43618
Gene name |
CNN1 (YFR046C) |
Protein name |
Inner kinetochore subunit CNN1 |
Names |
CENP-T homolog, Co-purified with NNF1 protein 1, Constitutive centromere-associated network protein CNN1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YFR046C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 variants for P43618
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s06-244110 | 13 | N>D | No | SGRP | |
| s06-243914 | 78 | A>V | No | SGRP | |
| s06-243837 | 104 | E>Q | No | SGRP | |
| s06-243792 | 119 | K>Q | No | SGRP | |
| s06-243770 | 126 | G>D | No | SGRP | |
| s06-243654 | 165 | P>S | No | SGRP | |
| s06-243603 | 182 | N>D | No | SGRP | |
| s06-243540 | 203 | P>S | No | SGRP | |
| s06-243387 | 254 | G>S | No | SGRP | |
| s06-243150 | 333 | I>V | No | SGRP |
No associated diseases with P43618
No regional properties for P43618
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P43618 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| centromeric DNA binding | Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. |
| protein-containing complex binding | Binding to a macromolecular complex. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| negative regulation of NMS complex assembly | Any process that stops, prevents or reduces the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTPRKAAGN | NENTEVSEIR | TPFRERALEE | QRLKDEVLIR | NTPGYRKLLS | ASTKSHDILN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDPNEVRSFL | QDLSQVLARK | SQGNDTTTNK | TQARNLIDEL | AYEESQPEEN | ELLRSRSEKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TDNNIGNETQ | PDYTSLSQTV | FAKLQERDKG | LKSRKIDPII | IQDVPTTGHE | DELTVHSPDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANSISMEVLR | TSPSIGMDQV | DEPPVRDPVP | ISITQQEEPL | SEDLPSDDKE | ETEEAENEDY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFENTSDENL | DDIGNDPIRL | NVPAVRRSSI | KPLQIMDLKH | LTRQFLNENR | IILPKQTWST |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IQEESLNIMD | FLKQKIGTLQ | KQELVDSFID | MGIINNVDDM | FELAHELLPL | ELQSRIESYL |
| F |