P43542
PR
Gene name |
COS4 (YFL062W) |
Protein name |
Protein COS4 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YFL062W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P43542
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P43542-F1 | Predicted | AlphaFoldDB |
85 variants for P43542
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s06-6444 | 7 | K>E | No | SGRP | |
| s06-6447 | 8 | N>D | No | SGRP | |
| s06-6459 | 12 | V>I | No | SGRP | |
| s06-6465 | 14 | V>I | No | SGRP | |
| s06-6474 | 17 | F>V | No | SGRP | |
| s06-6499 | 25 | I>T | No | SGRP | |
| s06-6516 | 31 | L>V | No | SGRP | |
| s06-6526 | 34 | S>N | No | SGRP | |
| s06-6528 | 35 | S>G | No | SGRP | |
| s06-6529 | 35 | S>N | No | SGRP | |
| s06-6530 | 35 | S>R | No | SGRP | |
| s06-6533 | 36 | F>L | No | SGRP | |
| s06-6560 | 45 | K>N | No | SGRP | |
| s06-6568 | 48 | A>V | No | SGRP | |
| s06-6570 | 49 | F>L | No | SGRP | |
| s06-6581 | 52 | W>C | No | SGRP | |
| s06-6631 | 69 | W>* | No | SGRP | |
| s06-6632 | 69 | W>C | No | SGRP | |
| s06-6633 | 70 | I>V | No | SGRP | |
| s06-6647 | 74 | M>I | No | SGRP | |
| s06-6657 | 78 | L>I | No | SGRP | |
|
s06-6671 s06-6670 |
82 | W>* | No | SGRP | |
| s06-6669 | 82 | W>G | No | SGRP | |
| s06-6670 | 82 | W>L | No | SGRP | |
| s06-6669 | 82 | W>R | No | SGRP | |
| s06-6676 | 84 | P>L | No | SGRP | |
| s06-6679 | 85 | V>A | No | SGRP | |
| s06-6678 | 85 | V>I | No | SGRP | |
| s06-6682 | 86 | F>S | No | SGRP | |
| s06-6684 | 87 | V>F | No | SGRP | |
| s06-6684 | 87 | V>L | No | SGRP | |
| s06-6688 | 88 | L>P | No | SGRP | |
| s06-6691 | 89 | V>A | No | SGRP | |
| s06-6697 | 91 | F>C | No | SGRP | |
| s06-6696 | 91 | F>L | No | SGRP | |
| s06-6697 | 91 | F>Y | No | SGRP | |
| s06-6699 | 92 | R>G | No | SGRP | |
| s06-6700 | 92 | R>K | No | SGRP | |
| s06-6700 | 92 | R>T | No | SGRP | |
| s06-6703 | 93 | L>P | No | SGRP | |
| s06-6706 | 94 | S>F | No | SGRP | |
| s06-6736 | 104 | T>I | No | SGRP | |
| s06-6753 | 110 | I>V | No | SGRP | |
| s06-6759 | 112 | K>E | No | SGRP | |
| s06-6763 | 113 | S>N | No | SGRP | |
| s06-6824 | 133 | L>F | No | SGRP | |
| s06-6847 | 141 | I>T | No | SGRP | |
| s06-6850 | 142 | R>K | No | SGRP | |
| s06-6865 | 147 | N>S | No | SGRP | |
| s06-6873 | 150 | G>S | No | SGRP | |
| s06-6988 | 188 | G>E | No | SGRP | |
| s06-7000 | 192 | R>T | No | SGRP | |
| s06-7029 | 202 | N>Y | No | SGRP | |
| s06-7032 | 203 | S>T | No | SGRP | |
| s06-7071 | 216 | K>E | No | SGRP | |
| s06-7110 | 229 | F>I | No | SGRP | |
| s06-7110 | 229 | F>V | No | SGRP | |
| s06-7115 | 230 | L>F | No | SGRP | |
| s06-7126 | 234 | S>F | No | SGRP | |
| s06-7131 | 236 | I>L | No | SGRP | |
| s06-7133 | 236 | I>M | No | SGRP | |
| s06-7136 | 237 | F>L | No | SGRP | |
| s06-7137 | 238 | M>V | No | SGRP | |
| s06-7142 | 239 | L>F | No | SGRP | |
| s06-7144 | 240 | I>T | No | SGRP | |
| s06-7147 | 241 | P>L | No | SGRP | |
| s06-7155 | 244 | N>Y | No | SGRP | |
| s06-7165 | 247 | C>Y | No | SGRP | |
| s06-7170 | 249 | I>L | No | SGRP | |
| s06-7173 | 250 | Y>H | No | SGRP | |
| s06-7186 | 254 | G>E | No | SGRP | |
| s06-7193 | 256 | C>* | No | SGRP | |
| s06-7197 | 258 | L>I | No | SGRP | |
| s06-7211 | 262 | L>F | No | SGRP | |
| s06-7235 | 270 | M>I | No | SGRP | |
| s06-7357 | 311 | R>K | No | SGRP | |
| s06-7389 | 322 | V>I | No | SGRP | |
| s06-7397 | 324 | K>N | No | SGRP | |
| s06-7407 | 328 | F>L | No | SGRP | |
| s06-7414 | 330 | F>Y | No | SGRP | |
| s06-7461 | 346 | V>L | No | SGRP | |
| s06-7485 | 354 | R>W | No | SGRP | |
| s06-7488 | 355 | A>P | No | SGRP | |
| s06-7489 | 355 | A>V | No | SGRP | |
| s06-7494 | 357 | S>P | No | SGRP |
No associated diseases with P43542
No regional properties for P43542
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P43542 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKENELKNEK | SVDVLSFKQL | ESQKIVLPQD | LFRSSFTWFC | YEIYKSLAFR | IWMLLWLPLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VWWKLSNNWI | YPLMVSLLVL | FWGPVFVLVI | FRLSRKRSLS | KQLTQFCKEI | TKSTPSSDPH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DWEVVAANLN | SYLYENKAWN | IRYFFFNAMG | CQEAFRTTLL | EPFSLKKDEA | AKVKSFKDSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PYIEEALGVY | FREVEKQWKL | FNSEKSWSPV | GLEDAKLPKE | AYRFKLTWFL | KRISNIFMLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PFLNFLCCIY | VSRGMCLLLR | TLYLGWILFM | LVQGFQNIRV | LIMSMEHKMQ | FLSTIINEQE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGANGWDEIA | RKMNRYLFEK | KVWKNEEFFF | DGIDCEWFFS | HFFYRVLSAK | KSMRALSLNV |
| 370 | |||||
| ELWPYIKEAQ | LSCSEESLA |