P43248

PR
Gene name
spel1 (CG4215)
Protein name
DNA mismatch repair protein spellchecker 1
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4215
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43248

Entry ID Method Resolution Chain Position Source
AF-P43248-F1 Predicted AlphaFoldDB

No variants for P43248

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43248

No associated diseases with P43248

5 regional properties for P43248

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 660 - 850 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 24 - 131 IPR007695
domain DNA mismatch repair protein MutS, core 303 - 643 IPR007696
domain DNA mismatch repair protein MutS, connector domain 145 - 287 IPR007860
domain DNA mismatch repair protein MutS, clamp 472 - 566 IPR007861

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
double-stranded DNA binding Binding to double-stranded DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

5 GO annotations of biological process

Name Definition
interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
maintenance of DNA repeat elements Any process involved in sustaining the fidelity and copy number of DNA repeat elements.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
mitotic recombination The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles.
postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43246 MSH2 DNA mismatch repair protein Msh2 Homo sapiens (Human) PR
10 20 30 40 50 60
MQAKATDSRQ EPTLNMDTNA RRNFIKFHAK LGEKPATTVR FFDHTDRYTV HGSDDCELVA
70 80 90 100 110 120
KIVYKSTAFI GALLPDDKKE TLQFVSMSKG NFELAVRELL LVRNYRVEVY VKNSSDWEIE
130 140 150 160 170 180
YRGSPGNLLQ FEDILFSNKE VLVGNSIISL LVKLDGGGQR RVGVASVEQN DCKFQLLEFL
190 200 210 220 230 240
DDDFFTELEA TVVLLGPKEC LLPSIEGEYS AVKTLLDRNG VMITMPKKSG DNDLLQDLNR
250 260 270 280 290 300
LLRFAKGQQE DATGLKELQL QLASNALKTA IKYLDLVNDA GNLGHYEIKQ LDLNRFVHLD
310 320 330 340 350 360
SAAVAALNIM PKPGTHPSMP SYRWQSVLGV LDHCRTPQGH RLMGQWVKQP LRSRNILNDR
370 380 390 400 410 420
HNIVQCLLES PDTMETLSLD YLKRIPDILM LTKKLMRRKA NLQDLFRIYQ VILRTPKILK
430 440 450 460 470 480
VLHELDNSTI ESVICAPFKS FLKDLTGLKQ MVEQVVDFEA IERGEYLVKA SFDSRLMELQ
490 500 510 520 530 540
QMMTELYSKM EELQFKCSQE LNLDGKNQVK LESVAKLGHH FRITVKDDSV LRKNKNYRIV
550 560 570 580 590 600
DVIKGGVRFT SDKLEGYADE FASCRTRYEE QQLSIVEEII HVAVGYAAPL TLLNNELAQL
610 620 630 640 650 660
DCLVSFAIAA RSAPTPYVRP KMLEEGAREL VLEDVRHPCL ELQEHVNFIA NSVDFKKEEC
670 680 690 700 710 720
NMFIITGPNM GGKSTYIRSV GTAVLMAHIG AFVPCSLATI SMVDSILGRV GASDNIIKGL
730 740 750 760 770 780
STFMVEMIET SGIIRTATDK SLVIIDELGR GTSTYEGCGI AWSIAEHLAK ETKCFTLFAT
790 800 810 820 830 840
HFHEITKLAE TLSTVKNCHM AAVADADDFT LLYQVRSGVM EKSFGIQVAR LANFPEHVVQ
850 860 870 880 890 900
NAQEVYNEFE DEHVDKQKKE DKALLEKIQV AIQQLSTAGN NVDINVEDLT QLVTQFTKDI
910
EQLDSDYFKS VLATSEA