Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P43156
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P43156-F1 | Predicted | AlphaFoldDB |
No variants for P43156
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P43156 | |||||
No associated diseases with P43156
6 regional properties for P43156
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 148 - 159 | IPR000169 |
| domain | Peptidase C1A, papain C-terminal | 130 - 345 | IPR000668 |
| domain | Cathepsin propeptide inhibitor domain (I29) | 40 - 96 | IPR013201 |
| active_site | Cysteine peptidase, histidine active site | 287 - 297 | IPR025660 |
| active_site | Cysteine peptidase, asparagine active site | 305 - 324 | IPR025661 |
| domain | Papain-like cysteine endopeptidase | 132 - 344 | IPR039417 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKPKFIALA | LVALSFLSIA | QSIPFTEKDL | ASEDSLWNLY | EKWRTHHTVA | RDLDEKNRRF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NVFKENVKFI | HEFNQKKDAP | YKLALNKFGD | MTNQEFRSKY | AGSKIQHHRS | QRGIQKNTGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FMYENVGSLP | AASIDWRAKG | AVTGVKDQGQ | CGSCWAFSTI | ASVEGINQIK | TGELVSLSEQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELVDCDTSYN | EGCNGGLMDY | AFEFIQKNGI | TTEDSYPYAE | QDGTCASNLL | NSPVVSIDGH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QDVPANNENA | LMQAVANQPI | SVSIEASGYG | FQFYSEGVFT | GRCGTELDHG | VAIVGYGATR |
| 310 | 320 | 330 | 340 | 350 | |
| DGTKYWIVKN | SWGEEWGESG | YIRMQRGISD | KRGKCGIAME | ASYPIKTSAN | PKNSSTRDEL |