P43152

PR
Gene name
Protein name
Hypoxanthine-guanine phosphoribosyltransferase
Names
HGPRT, HGPRTase
Species
Leishmania donovani
KEGG Pathway
ldo:LDBPK_210980
EC number
2.4.2.8: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43152

Entry ID Method Resolution Chain Position Source
AF-P43152-F1 Predicted AlphaFoldDB

No variants for P43152

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43152

No associated diseases with P43152

1 regional properties for P43152

Type Name Position InterPro Accession
domain Phosphoribosyltransferase domain 37 - 186 IPR000836

Functions

Description
EC Number 2.4.2.8 Pentosyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
guanine phosphoribosyltransferase activity Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.
hypoxanthine phosphoribosyltransferase activity Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

2 GO annotations of biological process

Name Definition
IMP salvage Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis.
purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNSAKSPSG PVGDEGRRNY PMSAHTLVTQ EQVWAATAKC AKKIAEDYRS FKLTTDNPLY
70 80 90 100 110 120
LLCVLKGSFI FTADLARFLA DEGVPVKVEF ICASSYGTGV ETSGQVRMLL DVRDSVENRH
130 140 150 160 170 180
ILIVEDIVDS AITLQYLMRF MLAKKPASLK TVVLLDKPSG RKVEVLVDYP VITIPHAFVI
190 200 210
GYGMDYAESY RELRDICVLK KEYYEKPESK V