P43068

PR
Gene name
MKC1
Protein name
Mitogen-activated protein kinase MKC1
Names
40 kDa allergen, Allergen Can a 1, Allergen Can a I, MAP kinase MKC1
Species
Candida albicans (Yeast)
KEGG Pathway
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

191-218 (Activation loop from InterPro)

Target domain

28-339 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P43068

Entry ID Method Resolution Chain Position Source
AF-P43068-F1 Predicted AlphaFoldDB

No variants for P43068

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43068

No associated diseases with P43068

3 regional properties for P43068

Type Name Position InterPro Accession
domain Protein kinase domain 28 - 339 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 80 - 186 IPR003527
active_site Serine/threonine-protein kinase, active site 170 - 182 IPR008271

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

7 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell wall integrity MAPK cascade A MAPK cascade that contributes to cell wall organization or biogenesis.
negative regulation of glucose mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway.
negative regulation of mitotic cytokinesis Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis.
positive regulation of calcium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQQEAPIYY GRSVNKVYNQ EFIIDSRFKI VKELGHGAYG IVCSAKYDNG SKKVPDSNNG
70 80 90 100 110 120
NASSSANASF VAIKKITNIF SKNILCKRAL RELKLLQFFR GHKNITCLYD LDIIPNPMTG
130 140 150 160 170 180
EFNEIYLYEE LMECDMHQII RSGQPLSDQH YQSFIYQVLC GLNFIHSADV LHRDLKPGNL
190 200 210 220 230 240
LVNADCELKI CDFGLARGFS ENPDENAGFM TEYVATRWYR APEIMLSFTN YTKAIDIWSV
250 260 270 280 290 300
GCILAELLGG KPLFRGKDYV DQLNQILMIL GTPPESTLQR IGSHRAQNYV RSLPITRKAS
310 320 330 340 350 360
YEELFPDANP LALDLLERML TLDPRERITV RDALNHKYLE LWHDPKEEIE CQVKFDFKSF
370 380 390 400 410 420
ETVDGLDEMK QLIMDEVQKF REFVRKPIEE QQRIQMQLHM QKREEQRQEE EEKELLEQQR
430 440 450 460 470 480
QFPAQESMDI SQTPYNNLET NIGTPQVEDD YPRPQELDEF TFSNLESSSS MNLFQDMAKP
490 500
SGEEYIKLEE ELGFGLDWCY V