P42843
Gene name |
SKP2 (YNL311C, N0376) |
Protein name |
F-box protein SKP2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNL311C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P42843
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42843-F1 | Predicted | AlphaFoldDB |
16 variants for P42843
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-51291 | 133 | T>A | No | SGRP | |
| s14-51200 | 163 | K>R | No | SGRP | |
| s14-51131 | 186 | D>G | No | SGRP | |
| s14-51081 | 203 | T>S | No | SGRP | |
| s14-51075 | 205 | E>K | No | SGRP | |
| s14-51049 | 213 | L>F | No | SGRP | |
| s14-50735 | 318 | F>S | No | SGRP | |
| s14-50640 | 350 | I>V | No | SGRP | |
| s14-50093 | 532 | N>I | No | SGRP | |
| s14-50093 | 532 | N>T | No | SGRP | |
| s14-49824 | 622 | A>T | No | SGRP | |
| s14-49775 | 638 | I>S | No | SGRP | |
| s14-49736 | 651 | C>Y | No | SGRP | |
| s14-49734 | 652 | L>V | No | SGRP | |
| s14-49728 | 654 | D>N | No | SGRP | |
| s14-49659 | 677 | N>D | No | SGRP |
No associated diseases with P42843
1 regional properties for P42843
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | F-box domain | 54 - 101 | IPR001810 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of sulfur amino acid metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRLQLFGRS | KYFSLVSSAA | KEEEEEEEGC | ADAKSLLHST | SHDIKSRSLR | FNDKSSLMCL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTKVLLLILR | TLDFNTLVTL | CQVNSRFYNL | ITNEFLFQNV | ILDSKLSLLK | FNALIHSEFH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TSNIVTHSGD | CSTQSRSQNA | RFLVRSIEFK | NPQSQDSLLK | YSKFYNKSGQ | DSIIAGSYKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSYDKDVKKL | NNIRLNDETP | IITSERIKLL | DKLESNYFHY | TYIELMLDII | DYLPNLTRVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSDVEPNFKI | PLWYSVFNDG | SRDFFKKIIK | GQQSITNEDL | RTFQLSKKFV | KEYESKYYSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRLKILEIKA | NNKRQRTFNR | QRHHQKLVLR | PSLFCCFGII | NELKLENVTI | DTESLDTPME |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLPLFLKNED | NELYSLQSPI | TALTLDSCDV | VPGNGILRLF | HSYFKMVKHL | SLLKINSKFD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLLCSCFPSL | SNLTIDCNSK | CFTNEQVVGE | SYYFQQRSLD | TEDDFDDCNS | MTETLFEAPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSKIITPPPT | SSVVLSLNLN | YISRTTGNDV | SNNPSPDNNK | KPAMLTAAQL | QNFQRQRIPE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FHSFYHYYRL | LWERLPSKNI | SINVINIPFT | NVYPLSPLSF | WEHLARTITS | VDETDEDVGD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ENDQETLIGY | ENNSIRDNIP | NANAVPNLST | VMSPESDIHH | TYYWNNSVRR | CLRDSLIKLK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NRTIEYRDLD | VEEFLQNVTL | ENFFNDFQDP | ENFKDIPNIN | LWCFLRNLSK | FKAVKIRMLR |
| 730 | 740 | 750 | 760 | ||
| HFSLCTPRTR | YDWELLLKPV | LRVNVPIEVR | DKDGFVLYSY | GQK |