P42841

PR
Gene name
PFS2 (YNL317W, N0348)
Protein name
Polyadenylation factor subunit 2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL317W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P42841

Entry ID Method Resolution Chain Position Source
6EOJ EM 355 A D 1-465 PDB
7ZGP EM 270 A D 1-465 PDB
7ZGQ EM 280 A D 1-465 PDB
7ZGR EM 260 A D 1-465 PDB
AF-P42841-F1 Predicted AlphaFoldDB

3 variants for P42841

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-41440 275 N>H No SGRP
s14-41899 428 L>F No SGRP
s14-41966 450 G>D No SGRP

No associated diseases with P42841

5 regional properties for P42841

Type Name Position InterPro Accession
repeat WD40 repeat 89 - 121 IPR001680-1
repeat WD40 repeat 124 - 163 IPR001680-2
repeat WD40 repeat 165 - 290 IPR001680-3
repeat WD40 repeat 294 - 333 IPR001680-4
repeat WD40 repeat 338 - 378 IPR001680-5

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
pre-mRNA cleavage required for polyadenylation The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.
termination of RNA polymerase II transcription, poly(A)-coupled An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDGHNQNQYQ NQNQIQQSQQ PPLKKYVTQR RSVDVSSPYI NLYYNRRHGL PNLVVEPETS
70 80 90 100 110 120
YTIDIMPPNA YRGRDRVINL PSKFTHLSSN KVKHVIPAIQ WTPEGRRLVV ATYSGEFSLW
130 140 150 160 170 180
NASSFTFETL MQAHDSAVTT MKYSHDSDWM ISGDADGMIK IWQPNFSMVK EIDAAHTESI
190 200 210 220 230 240
RDMAFSSNDS KFVTCSDDNI LKIWNFSNGK QERVLSGHHW DVKSCDWHPE MGLIASASKD
250 260 270 280 290 300
NLVKLWDPRS GNCISSILKF KHTVLKTRFQ PTKGNLLMAI SKDKSCRVFD IRYSMKELMC
310 320 330 340 350 360
VRDETDYMTL EWHPINESMF TLACYDGSLK HFDLLQNLNE PILTIPYAHD KCITSLSYNP
370 380 390 400 410 420
VGHIFATAAK DRTIRFWTRA RPIDPNAYDD PTYNNKKING WFFGINNDIN AVREKSEFGA
430 440 450 460
APPPPATLEP HALPNMNGFI NKKPRQEIPG IDSNIKSSTL PGLSI