P42800
Gene name |
INO1 (CAALFM_CR10100CA, CaO19.7585) |
Protein name |
Inositol-3-phosphate synthase |
Names |
MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase |
Species |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
KEGG Pathway |
cal:CAALFM_CR10100CA |
EC number |
5.5.1.4: Intramolecular lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P42800
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42800-F1 | Predicted | AlphaFoldDB |
No variants for P42800
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P42800 | |||||
No associated diseases with P42800
1 regional properties for P42800
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Myo-inositol-1-phosphate synthase, GAPDH-like | 316 - 431 | IPR013021 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.5.1.4 | Intramolecular lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| hyphal cell wall | The cell wall surrounding a fungal hypha. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol-3-phosphate synthase activity | Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| inositol biosynthetic process | The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTPIEFKSS | NSVTKDDHLY | TKFTYENSVV | EKDANGKFIV | TPTASDYEFK | VDLKVPKVGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLVGIGGNNG | TTLLGATLAN | KHNISFENKE | GVVKPNYYGS | VTQASTVKIG | VDKETGEDVY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPFNSIVPMV | NPNDLVVDGW | DISGLPLDQA | MKRAKVLDVT | LQKQLYPYLE | NKKPLESIYY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PDFIALNQSE | RANNVFNQVN | GEVKTDNKWA | DVEKIRKDIR | DFKAKNELDK | VIILWTANTE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RYADVLPNVN | DTADNLIKSI | KESHEEIAPS | TVFAVASILE | KVPYINGSPQ | NTFVPGVIEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEKYDSFIGG | DDFKSGQTKI | KSVLAQFLVD | AGIKPLSIAS | YNHLGNNDGY | NLSSPKQFRS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KEISKQSVVD | DIIESNELLY | NKESGDKVDH | CIVIKYLPAV | GDSKVAMDEY | YSELMLGGHN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KISIHNVCED | SLLATPLIID | LVVATEFATR | VQVKGPGKSD | YDELYPVASL | LSYWLKAPLA |
| 490 | 500 | 510 | |||
| RPGFKPINGL | NKQRQQLVNL | LSVLVGLPID | NELRFERILK |