P42745

PR
Gene name
UBC2 (At2g02760, T20F6.10)
Protein name
Ubiquitin-conjugating enzyme E2 2
Names
E2 ubiquitin-conjugating enzyme 2, Ubiquitin carrier protein 2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G02760
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P42745

Entry ID Method Resolution Chain Position Source
AF-P42745-F1 Predicted AlphaFoldDB

5 variants for P42745

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_774823_G_T 96 W>L No 1000Genomes
tmp_2_774825_A_T 97 S>C No 1000Genomes
tmp_2_774837_G_A 101 D>N No 1000Genomes
tmp_2_774841_T_G 102 V>G No 1000Genomes
ENSVATH10717779 131 S>R No 1000Genomes

No associated diseases with P42745

2 regional properties for P42745

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 4 - 150 IPR000608
active_site Ubiquitin-conjugating enzyme, active site 77 - 92 IPR023313

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

7 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
histone H2B ubiquitination The modification of histone H2B by addition of ubiquitin groups.
histone ubiquitination The modification of histones by addition of ubiquitin groups.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
vegetative to reproductive phase transition of meristem The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTPARKRLM RDFKRLQQDP PAGISGAPQD NNIMLWNAVI FGPDDTPWDG GTFKLSLQFS
70 80 90 100 110 120
EDYPNKPPTV RFVSRMFHPN IYADGSICLD ILQNQWSPIY DVAAILTSIQ SLLCDPNPNS
130 140 150
PANSEAARMF SESKREYNRR VREVVEQSWT AD