P42690

PR
Gene name
SRK1
Protein name
Tyrosine-protein kinase isoform SRK4
Names
Species
Spongilla lacustris (Freshwater sponge)
KEGG Pathway
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P42690

Entry ID Method Resolution Chain Position Source
AF-P42690-F1 Predicted AlphaFoldDB

No variants for P42690

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P42690

No associated diseases with P42690

7 regional properties for P42690

Type Name Position InterPro Accession
domain Protein kinase domain 240 - 493 IPR000719
domain SH2 domain 120 - 214 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 240 - 488 IPR001245
domain SH3 domain 54 - 116 IPR001452
active_site Tyrosine-protein kinase, active site 355 - 367 IPR008266
binding_site Protein kinase, ATP binding site 246 - 268 IPR017441
domain Tyrosine-protein kinase, catalytic domain 240 - 489 IPR020635

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP AQDVKYPIYV
70 80 90 100 110 120
GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA GKEGYIPSNY VAEYKSLDAE
130 140 150 160 170 180
EWFFGQVKRV DAEKQLMMPF NNLGSFLIRD SDTTPGDFSL SVRDIDRVRH YRIKKLENGT
190 200 210 220 230 240
YFVTRRLTFQ SIQELVAYYT QQADGLCVNL KGPCMVMEKP QTAGLSKQAN EEWEIEKKQI
250 260 270 280 290 300
KLLRGLGAGQ FGEVWEGLWN GTTSVAVKTL KPGTMSIEEF LEEASIMKQL RHPKLIQLYA
310 320 330 340 350 360
VCTKEEPIYI VTELMKHGSL LEYLRGDGRS LKLPDLVDMC SQVASGMSYL EQQNYIHRDL
370 380 390 400 410 420
AARNILVGEH KICKVADFGL ARVIDEEIYE AKLGAKFPIK WTAPEAAMYS RFTIKSDVWS
430 440 450 460 470 480
FGIVLYEVIT YGRFPYPGMT NAQVLEQIQQ SYRMPRPMGC PEKLYAIMMD CWREDPASRP
490 500
TFETLSWQLE EFFTTGDDAG YKDMER