P42689

PR
Gene name
SRK3
Protein name
Tyrosine-protein kinase SRK3
Names
Species
Spongilla lacustris (Freshwater sponge)
KEGG Pathway
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

203-227 (Activation loop from InterPro)

Target domain

66-321 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P42689

Entry ID Method Resolution Chain Position Source
AF-P42689-F1 Predicted AlphaFoldDB

No variants for P42689

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P42689

No associated diseases with P42689

6 regional properties for P42689

Type Name Position InterPro Accession
domain Protein kinase domain 66 - 321 IPR000719
domain SH2 domain 1 - 42 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 66 - 315 IPR001245
active_site Tyrosine-protein kinase, active site 182 - 194 IPR008266
binding_site Protein kinase, ATP binding site 72 - 94 IPR017441
domain Tyrosine-protein kinase, catalytic domain 66 - 316 IPR020635

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
IRTLDDGGFY MANRISFPTL QNLVSHYMMD ADGLAQRLSR PCSRANIPIT SGLSYKDEWE
70 80 90 100 110 120
IDRTTIQLQR KLGQGNFGEV WAGVWNGTTA VAVKTLKPDT MEVKDFVQEA QVMKKIHHPN
130 140 150 160 170 180
LLQLYAVCTI GEPIYIVTEL MKYGSMLEYL KHGEGKNITL HQMVDMSAQI ASGMTYLEAH
190 200 210 220 230 240
SYIHRDLAAR NILVGEGNVC KVADFGLARV IKEDIYNPRE GTKFPIKWTA PEAALYNRFT
250 260 270 280 290 300
IKSDVWSFGV LISEIVTHGR MPYPGMTNRQ VLEAVDRGYR MPCPEGCPDP LYKIMLSCWK
310 320 330
HEPDDRPTFE SLKNLLEDYY VSAAEGSYRE PAPR