P42686

PR
Gene name
SRK1
Protein name
Tyrosine-protein kinase isoform SRK1
Names
Species
Spongilla lacustris (Freshwater sponge)
KEGG Pathway
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

376-400 (Activation loop from InterPro)

Target domain

240-493 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P42686

Entry ID Method Resolution Chain Position Source
AF-P42686-F1 Predicted AlphaFoldDB

No variants for P42686

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P42686

No associated diseases with P42686

7 regional properties for P42686

Type Name Position InterPro Accession
domain Protein kinase domain 240 - 493 IPR000719
domain SH2 domain 120 - 214 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 240 - 488 IPR001245
domain SH3 domain 54 - 116 IPR001452
active_site Tyrosine-protein kinase, active site 355 - 367 IPR008266
binding_site Protein kinase, ATP binding site 246 - 268 IPR017441
domain Tyrosine-protein kinase, catalytic domain 240 - 489 IPR020635

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP AQDVKYPIYV
70 80 90 100 110 120
GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA GKEGYIPSNY VAEYKSLDAE
130 140 150 160 170 180
EWFLGKIKRV EAEKMLNQSF NQVGSFLIRD SETTPGDFSL SVKDQDRVRH YRVRRLEDGS
190 200 210 220 230 240
LFVTRRSTFQ ILHELVDHYK IETDGLCCKL LYPCLQAEKP QTAGLLRQAN EEWEIEKTQI
250 260 270 280 290 300
KLLRRLGAGQ FGEVWEGLWN GTTSVAVKTL KPGTMSVEEF LQEASIMKRL RHPKLIQLYA
310 320 330 340 350 360
VCTKEEPIYI VTELMKYGSL LEYLRGEDGV LKIEQLVDVA AQVASGMSYL EQQNYIHRDL
370 380 390 400 410 420
AARNILVGEH GICKVADFGL ARVIDEEIYE AHTGAKFPIK WTAPEAAMYN RFTIKSDVWS
430 440 450 460 470 480
FGVVLYEIIT YGRFPYPGMT NPEVLEKIQQ NYRMPCPANC PKQFHDIMLD CWREDPASRP
490 500
TFETLQWQLE EFFNSEGYRD PDAIH