P42632

PR
Gene name
tdcE (yhaS, b3114, JW5522)
Protein name
PFL-like enzyme TdcE
Names
Keto-acid formate acetyltransferase, Keto-acid formate-lyase, Ketobutyrate formate-lyase, KFL, Pyruvate formate-lyase, PFL
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3114
EC number
2.3.1.54: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

596-677 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P42632

Entry ID Method Resolution Chain Position Source
AF-P42632-F1 Predicted AlphaFoldDB

No variants for P42632

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P42632

No associated diseases with P42632

3 regional properties for P42632

Type Name Position InterPro Accession
domain Glycine radical domain 634 - 764 IPR001150
domain Pyruvate formate lyase domain 7 - 629 IPR004184
conserved_site Formate C-acetyltransferase glycine radical, conserved site 734 - 742 IPR019777

Functions

Description
EC Number 2.3.1.54 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
2-ketobutyrate formate-lyase activity Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate.
formate C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.

3 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
L-threonine catabolic process to propionate The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate.
threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVDIDTSDK LYADAWLGFK GTDWKNEINV RDFIQHNYTP YEGDESFLAE ATPATTELWE
70 80 90 100 110 120
KVMEGIRIEN ATHAPVDFDT NIATTITAHD AGYINQPLEK IVGLQTDAPL KRALHPFGGI
130 140 150 160 170 180
NMIKSSFHAY GREMDSEFEY LFTDLRKTHN QGVFDVYSPD MLRCRKSGVL TGLPDGYGRG
190 200 210 220 230 240
RIIGDYRRVA LYGISYLVRE RELQFADLQS RLEKGEDLEA TIRLREELAE HRHALLQIQE
250 260 270 280 290 300
MAAKYGFDIS RPAQNAQEAV QWLYFAYLAA VKSQNGGAMS LGRTASFLDI YIERDFKAGV
310 320 330 340 350 360
LNEQQAQELI DHFIMKIRMV RFLRTPEFDS LFSGDPIWAT EVIGGMGLDG RTLVTKNSFR
370 380 390 400 410 420
YLHTLHTMGP APEPNLTILW SEELPIAFKK YAAQVSIVTS SLQYENDDLM RTDFNSDDYA
430 440 450 460 470 480
IACCVSPMVI GKQMQFFGAR ANLAKTLLYA INGGVDEKLK IQVGPKTAPL MDDVLDYDKV
490 500 510 520 530 540
MDSLDHFMDW LAVQYISALN IIHYMHDKYS YEASLMALHD RDVYRTMACG IAGLSVATDS
550 560 570 580 590 600
LSAIKYARVK PIRDENGLAV DFEIDGEYPQ YGNNDERVDS IACDLVERFM KKIKALPTYR
610 620 630 640 650 660
NAVPTQSILT ITSNVVYGQK TGNTPDGRRA GTPFAPGANP MHGRDRKGAV ASLTSVAKLP
670 680 690 700 710 720
FTYAKDGISY TFSIVPAALG KEDPVRKTNL VGLLDGYFHH EADVEGGQHL NVNVMNREML
730 740 750 760
LDAIEHPEKY PNLTIRVSGY AVRFNALTRE QQQDVISRTF TQAL