Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P42583
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42583-F1 | Predicted | AlphaFoldDB |
No variants for P42583
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P42583 | |||||
No associated diseases with P42583
4 regional properties for P42583
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 122 - 186 | IPR001356 |
| conserved_site | Homeobox, conserved site | 157 - 180 | IPR017970 |
| domain | Homeobox domain, metazoa | 146 - 157 | IPR020479-1 |
| domain | Homeobox domain, metazoa | 161 - 180 | IPR020479-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| protein-DNA complex | A macromolecular complex containing both protein and DNA molecules. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle contraction | Muscle contraction of cardiac muscle tissue. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| regulation of cardiac conduction | Any process that modulates the frequency, rate or extent of cardiac conduction. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFASPVTSTP | FSVKDILNLE | QHQSGLSPMD | ITSRLENSSC | MLSTFKQESY | PGTPCLSELT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEMSQRDTAK | GPSSFPGSFF | VKNYLEMDSK | DPKDHKKDIC | PLQKTLEHDK | REAEDPERPR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QRKRRKPRVL | FSQAQVYELE | RRFKQQKYLS | APERDHLANV | LKLTSTQVKI | WFQNRRYKCK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQRQDQTLEM | VGLPPPRRIA | VPVLVRDGKP | CLGESSPYNS | PYNVSINPYS | YNTYPAYSNY |
| 250 | 260 | 270 | 280 | 290 | |
| SNPACSGSYN | CSYSSMPSMQ | PTSAGNNFMN | FSVGDLNTVQ | TPIQQASSVS | ALHHGIRAW |