P42449
Gene name |
aceA |
Protein name |
Isocitrate lyase |
Names |
ICL, Isocitrase, Isocitratase |
Species |
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) |
KEGG Pathway |
cgl:Cgl2331 |
EC number |
4.1.3.1: Oxo-acid-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P42449
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42449-F1 | Predicted | AlphaFoldDB |
No variants for P42449
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P42449 | |||||
No associated diseases with P42449
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.3.1 | Oxo-acid-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| isocitrate lyase activity | Catalysis of the reaction: isocitrate = glyoxylate + succinate. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glyoxylate cycle | A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNVGKPRTA | QEIQQDWDTN | PRWNGITRDY | TADQVADLQG | SVIEEHTLAR | RGSEILWDAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TQEGDGYINA | LGALTGNQAV | QQVRAGLKAV | YLSGWQVAGD | ANLSGHTYPD | QSLYPANSVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVVRRINNAL | LRSDEIARTE | GDTSVDNWVV | PIVADGEAGF | GGALNVYELQ | KAMIAAGAAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| THWEDQLASE | KKCGHLGGKV | LIPTQQHIRT | LNSARLAADV | ANTPTVVIAR | TDAEAATLIT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDVDERDQPF | ITGERTAEGY | YHVKNGLEPC | IARAKSYAPY | ADMIWMETGT | PDLELAKKFA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGVRSEFPDQ | LLSYNCSPSF | NWSAHLEADE | IAKFQKELGA | MGFKFQFITL | AGFHSLNYGM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDLAYGYARE | GMTSFVDLQN | REFKAAEERG | FTAVKHQREV | GAGYFDQIAT | TVDPNSSTTA |
| 430 | |||||
| LKGSTEEGQF | HN |