P42443
Gene name |
recA |
Protein name |
Protein RecA |
Names |
Recombinase A |
Species |
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) |
KEGG Pathway |
dra:DR_2340 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P42443
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1XP8 | X-ray | 250 A | A | 1-363 | PDB |
| AF-P42443-F1 | Predicted | AlphaFoldDB |
1 variants for P42443
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 224 | G>S | rec30; DNA-repair deficient [UniProt] | No |
No associated diseases with P42443
4 regional properties for P42443
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 70 - 241 | IPR003593 |
| conserved_site | DNA recombination/repair protein RecA, conserved site | 226 - 234 | IPR020584 |
| domain | DNA recombination and repair protein RecA, monomer-monomer interface | 212 - 286 | IPR020587 |
| domain | DNA recombination and repair protein RecA-like, ATP-binding domain | 48 - 207 | IPR020588 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| damaged DNA binding | Binding to damaged DNA. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| double-strand break repair | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. |
| SOS response | An error-prone process for repairing damaged microbial DNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKDATKEIS | APTDAKERSK | AIETAMSQIE | KAFGKGSIMK | LGAESKLDVQ | VVSTGSLSLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LALGVGGIPR | GRITEIYGPE | SGGKTTLALA | IVAQAQKAGG | TCAFIDAEHA | LDPVYARALG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VNTDELLVSQ | PDNGEQALEI | MELLVRSGAI | DVVVVDSVAA | LTPRAEIEGD | MGDSLPGLQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLMSQALRKL | TAILSKTGTA | AIFINQVREK | IGVMYGNPET | TTGGRALKFY | ASVRLDVRKI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GQPTKVGNDA | VANTVKIKTV | KNKVAAPFKE | VELALVYGKG | FDQLSDLVGL | AADMDIIKKA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSFYSYGDER | IGQGKEKTIA | YIAERPEMEQ | EIRDRVMAAI | RAGNAGEAPA | LAPAPAAPEA |
| AEA |