P42428
Gene name |
tfdDII (tfdD2, Reut_D6474) |
Protein name |
Chloromuconate cycloisomerase |
Names |
Muconate cycloisomerase II |
Species |
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134)) |
KEGG Pathway |
reu:Reut_D6474 |
EC number |
5.5.1.7: Intramolecular lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P42428
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42428-F1 | Predicted | AlphaFoldDB |
No variants for P42428
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P42428 | |||||
No associated diseases with P42428
4 regional properties for P42428
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Mandelate racemase/muconate lactonizing enzyme, N-terminal domain | 11 - 118 | IPR013341 |
| domain | Mandelate racemase/muconate lactonizing enzyme, C-terminal | 137 - 234 | IPR013342 |
| conserved_site | Mandelate racemase/muconate lactonizing enzyme, conserved site | 93 - 118 | IPR018110 |
| domain | Enolase C-terminal domain-like | 142 - 353 | IPR029065 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.5.1.7 | Intramolecular lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloromuconate cycloisomerase activity | Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. |
| manganese ion binding | Binding to a manganese ion (Mn). |
| muconate cycloisomerase activity | Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| aromatic compound catabolic process | The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. |
| cellular amino acid catabolic process | The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIVDLPLRRI | QQFARLGAKH | QSSVLIRLHT | KGGIVGIGES | ITPCGPWWSG | DSVEAIQATI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NHYLAPLVVG | EPALDASRIM | AKLHGRVAGN | AFAKAGIEMA | LLDAVGKIVD | APIHVLLGGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FRDRLSVAWP | LATGDVNQEV | DEAFRMLEAG | KAGAFKLKMG | ALPLAQDLRR | ALAIAKELEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KASLRVDPNE | AWDEPTTMRA | LAPLEAAGVE | IIEQPVARWN | LDAMARIHRQ | ARSMLLIDEG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VQSLHDASEV | VKRAAAGLVS | LKIMKTGGMR | PARAMADIAN | AGGMHVYMGT | FLETSIGTAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NMQLAASIES | LPYGGEVIGP | LLIEEDLCEV | PAVYKEHALW | LPEGPGLGIR | LDENQVRRFA |
| 370 | |||||
| RASSQRIDRH | SA |