P42390
Gene name |
BX1 |
Protein name |
Indole-3-glycerol phosphate lyase, chloroplastic |
Names |
Benzoxazineless 1, Indole synthase, Tryptophan synthase alpha chain |
Species |
Zea mays (Maize) |
KEGG Pathway |
zma:542117 |
EC number |
4.1.2.8: Aldehyde-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P42390
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1RD5 | X-ray | 202 A | A/B | 87-347 | PDB |
| 1TJR | X-ray | 230 A | A/B | 87-347 | PDB |
| AF-P42390-F1 | Predicted | AlphaFoldDB |
5 variants for P42390
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| PZE0402846697 | 12 | S>L | No | EnsemblPlants | |
| PZE0402847379 | 200 | K>N | No | EnsemblPlants | |
| PZE0402847525 | 218 | H>Y | No | EnsemblPlants | |
| PZE0402847557 | 228 | N>K | No | EnsemblPlants | |
| PZE0402847940 | 286 | N>T | No | EnsemblPlants |
No associated diseases with P42390
1 regional properties for P42390
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Tryptophan synthase, alpha chain, active site | 134 - 147 | IPR018204 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.2.8 | Aldehyde-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| indole-3-glycerol-phosphate lyase activity | Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. |
| tryptophan synthase activity | Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tryptophan biosynthetic process | The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFAPKTSSS | SSLSSALQAA | QSPPLLLRRM | SSTATPRRRY | DAAVVVTTTT | TARAAAAAVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPAAPPQAPA | PAPVPPKQAA | APAERRSRPV | SDTMAALMAK | GKTAFIPYIT | AGDPDLATTA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EALRLLDGCG | ADVIELGVPC | SDPYIDGPII | QASVARALAS | GTTMDAVLEM | LREVTPELSC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVVLLSYYKP | IMSRSLAEMK | EAGVHGLIVP | DLPYVAAHSL | WSEAKNNNLE | LVLLTTPAIP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDRMKEITKA | SEGFVYLVSV | NGVTGPRANV | NPRVESLIQE | VKKVTNKPVA | VGFGISKPEH |
| 310 | 320 | 330 | 340 | ||
| VKQIAQWGAD | GVIIGSAMVR | QLGEAASPKQ | GLRRLEEYAR | GMKNALP |