AiPD: Autoinhibited Protein Database

Gene name	mutM (fpg)
Protein name	Formamidopyrimidine-DNA glycosylase
Names	Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM
Species	Lactococcus lactis subsp cremoris (Streptococcus cremoris)
KEGG Pathway
EC number	3.2.2.23: Hydrolyzing N-glycosyl compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

105-185 (Predicted disordered autoinhibitory region) PR

105-185 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1KFV	X-ray	255 A	A/B	2-273	PDB
1NNJ	X-ray	190 A	A	2-273	PDB
1PJI	X-ray	190 A	A	2-273	PDB
1PJJ	X-ray	190 A	A	2-273	PDB
1PM5	X-ray	195 A	A	2-273	PDB
1TDZ	X-ray	180 A	A	1-273	PDB
1XC8	X-ray	195 A	A	2-273	PDB
2XZF	X-ray	180 A	A	2-273	PDB
2XZU	X-ray	182 A	A	2-273	PDB
3C58	X-ray	190 A	A	2-273	PDB
4PCZ	X-ray	170 A	A	2-273	PDB
4PD2	X-ray	165 A	A	2-273	PDB
4PDG	X-ray	240 A	A	2-273	PDB
4PDI	X-ray	210 A	A	2-273	PDB
6H0S	X-ray	175 A	A	2-273	PDB
6RNM	X-ray	176 A	A	2-273	PDB
6RNO	X-ray	225 A	A	2-273	PDB
6RO2	X-ray	182 A	A	2-273	PDB
6ROK	X-ray	195 A	A	2-273	PDB
6RP0	X-ray	225 A	A	2-273	PDB
6RP7	X-ray	200 A	A	2-273	PDB
AF-P42371-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P42371

Type	Name	Position	InterPro Accession
domain	Zinc finger, DNA glycosylase/AP lyase-type	238 - 272	IPR000214
domain	Zinc finger, FPG/IleRS-type	244 - 271	IPR010663
domain	Formamidopyrimidine-DNA glycosylase, catalytic domain	1 - 116	IPR012319
domain	DNA glycosylase/AP lyase, H2TH DNA-binding	132 - 225	IPR015886
binding_site	DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site	247 - 271	IPR015887

		Description
EC Number	3.2.2.23	Hydrolyzing N-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
damaged DNA binding	Binding to damaged DNA.
oxidized purine nucleobase lesion DNA N-glycosylase activity	Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
base-excision repair	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins