P42118

PR
Gene name
dntt (tdt)
Protein name
DNA nucleotidylexotransferase
Names
Terminal addition enzyme, Terminal deoxynucleotidyltransferase, TDT, Terminal transferase
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:378525
EC number
2.7.7.31: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P42118

Entry ID Method Resolution Chain Position Source
AF-P42118-F1 Predicted AlphaFoldDB

No variants for P42118

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P42118

No associated diseases with P42118

7 regional properties for P42118

Type Name Position InterPro Accession
domain BRCT domain 27 - 124 IPR001357
domain DNA-directed DNA polymerase X 159 - 506 IPR002054
domain DNA polymerase beta-like, N-terminal domain 163 - 226 IPR010996
domain DNA polymerase lambda, fingers domain 246 - 295 IPR018944
binding_site DNA polymerase family X, binding site 328 - 347 IPR019843
domain DNA polymerase beta, palm domain 300 - 369 IPR028207
domain DNA polymerase beta, thumb domain 443 - 506 IPR029398

Functions

Description
EC Number 2.7.7.31 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA nucleotidylexotransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPLSQSALV PLRKKAKMAP ISQSFCQHNV KFKEIVLFLV ERKMGSSRRT FLMELARKRG
70 80 90 100 110 120
FQTEIELSDS VTHIVAENNS GAEVLEWLQS KKLGFTVKTH ILDISWFTEC MEAGRPVEIQ
130 140 150 160 170 180
NRHLLPVQQD CSANFNPPLS SSCVQVSQYA CQRCTTLQDT NRIFTDAFDI LAEHFEFCEN
190 200 210 220 230 240
KGRTVAFLRA SSLIKSLPFP ITAMKELEGL PWLGDQMKGI IEEILEEGKS YKVLEVMNEE
250 260 270 280 290 300
RYKSFKQFTS VFGVGLKTSD KWFRMGFRTL EEIKNEKELK LTKMQKCGLL YYEDITSYVS
310 320 330 340 350 360
RAEAETTEQL IKSIVWKFVP DAIVTLTGGF RRGKKKGHDV DILITCARKG KEKNILHNTM
370 380 390 400 410 420
SVLKNRGLLL FYNIIESTFD ETKLPSRHVD ALDHFQKCFT ILKLPKRQMD IGNIIDPHEC
430 440 450 460 470 480
ERKNWKAVRL DLVITPYEQY PYALLGWTGS RQFERDLRRY ATHEKRMMLD NHGLYDKTKN
490 500
NFLKANNEED IFKQLGLDYL EPWERNA