P41892

PR
Gene name
cdc7 (SPBC21.06c)
Protein name
Cell division control protein 7
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC21.06c
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

246-510 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

148-169 (Activation loop from InterPro)

Target domain

9-259 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P41892

Entry ID Method Resolution Chain Position Source
AF-P41892-F1 Predicted AlphaFoldDB

No variants for P41892

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41892

No associated diseases with P41892

3 regional properties for P41892

Type Name Position InterPro Accession
domain Protein kinase domain 9 - 259 IPR000719
active_site Serine/threonine-protein kinase, active site 127 - 139 IPR008271
binding_site Protein kinase, ATP binding site 15 - 39 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
new mitotic spindle pole body The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize.
old mitotic spindle pole body The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

6 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of mitotic division septum assembly Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of protein localization to mitotic spindle pole body Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body.
septation initiation signaling The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHNIQASSIT LGDCLGKGAF GAVYRGLNIK NGETVAVKKV KLSKMLKSDL SVIKMEIDLL
70 80 90 100 110 120
KNLDHPNIVK YRGSYQTNDS LCIILEYCEN GSLRSICKNF GKIPENLVAL YTFQVLQGLL
130 140 150 160 170 180
YLHNQGVIHR DIKGANILTT KDGTIKLADF GVATKINALE DHSVVGSPYW MAPEVIELVG
190 200 210 220 230 240
ATTASDIWSV GCTVIELLDG NPPYYDLDPT SALFRMVKDE HPPLPSNISS AAKSFLMQCF
250 260 270 280 290 300
QKDPNLRIKT RKLLKHPWVI MNQTSSKFSD AIDEVQKYNE RVKESTLTAI IEPTSNRINP
310 320 330 340 350 360
TLHSGRQSSY HMPESPKTPI AESPDHDNWD NEFQGTLKIS DDVLKKSEHF MDFCSNFKGK
370 380 390 400 410 420
NNSSSITSSP SKSRHAFNSD QISESNNFNA SPLSTPLKAQ FDPSKPALNR SIDHQKTPQH
430 440 450 460 470 480
KRYLSTEFKE NIPDGIEKFV ETPRDSEFTD IFPTSSIKVQ GLRKETGLGT LVLNKCYGSW
490 500 510 520 530 540
NNEENEDGEE SDIFDSIETN LENLDIENNI ALDKRTHLAS LLSSLLGSLR DKNIGSKDTT
550 560 570 580 590 600
VSQIASILSE DLSLKREIIQ AHGILPLLET LREIKTPDVQ LLLLKLINTV AFDDHTTLQK
610 620 630 640 650 660
VCFAGGLPLM LSFSNREHSF EFRYESAIFI QQMYRTSALT LQMFLSSNGL NSLLLFIKED
670 680 690 700 710 720
YGTNRDFVFV GVEGIWKLLR QQDYIPKNDI CTMVVNDSLE PLTKAMLKAL ATDDDSSRMS
730 740 750 760 770 780
LTRICEILLA LSQADNYVKE SLLCESALRR ILRILLYLPH SDMAITLQFF KQLSMVPSSL
790 800 810 820 830 840
SLLRKVHIIP LLTHILGDSK IEKGRKEIRS EALAALFNVC KLDKKSQEEA VISGAIPLLQ
850 860 870 880 890 900
EVIIKDRLFK EFALPILLAL PQAGPVSRIY LWQNKCLDFF LSLLSDLNWQ SAVFDTIASW
910 920 930 940 950 960
LQFELREVQR VLAEKRNVQL VLKVFCISQS ASSNRMLDTL GRVCQISPRL AASYGQPIIF
970 980 990 1000 1010 1020
QKFKEKLTHK GTKPIVVLNI FQIMKSMCEA SSQSVAYIAH CGLPDVVANL NQTSDSVLVK
1030 1040 1050 1060
ELAKDLLKYL KVPQGPINEH KSPISKPHMP PPRWQPKQPL TQ