P41836
Gene name |
let1 (SPBC23G7.12c) |
Protein name |
26S proteasome regulatory subunit 8 homolog |
Names |
Protein let1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC23G7.12c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P41836
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P41836-F1 | Predicted | AlphaFoldDB |
No variants for P41836
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P41836 | |||||
No associated diseases with P41836
5 regional properties for P41836
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 178 - 318 | IPR003593 |
| domain | ATPase, AAA-type, core | 182 - 315 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 286 - 304 | IPR003960 |
| domain | Proteasomal ATPase OB C-terminal domain | 69 - 124 | IPR032501 |
| domain | AAA ATPase, AAA+ lid domain | 339 - 381 | IPR041569 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| proteasome regulatory particle, base subcomplex | The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| proteasome-activating activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of mitotic metaphase/anaphase transition | Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEVLKTNVL | QSNENIVQYY | TQKIQDAELA | ILQKTQNLRR | LEAQRNGLNA | RVRLLREEIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLQEPGSYVG | EVIKTMGKNK | VLVKVHPEGK | YVVDISPDID | IKEIKPNIRV | ALRNDSYQLI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KILPNKVDPL | VSLMMVEKIP | DSTYEMVGGL | EKQIKEIKEV | IELPVKHPEL | FESLGIPQPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GILLYGPPGT | GKTLLARAVA | HHTDCKFIRV | SGSELVQKYI | GEGSRMVREL | FVMAREHAPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIFMDEIDSI | GSSRSDSSGG | SGDSEVQRTM | LELLNQLDGF | EATKNIKVIM | ATNRIDILDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALLRPGRIDR | KIEFPPPSAE | ARAEILRIHS | RSMNLTRGID | LKSIAEKMNG | ASGAELKGVC |
| 370 | 380 | 390 | 400 | ||
| TEAGMFALRE | RRVHVTQEDF | ELAVAKVLNK | GDSGEMSLQK | LFK |