P41819

PR
Gene name
DIM1
Protein name
Dimethyladenosine transferase
Names
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, 18S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL266W
EC number
2.1.1.183: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for P41819

Entry ID Method Resolution Chain Position Source
6RBD EM 347 A y 1-318 PDB
6ZQD EM 380 A JL 1-318 PDB
6ZQE EM 710 A JL 1-318 PDB
6ZQF EM 490 A JL 1-318 PDB
6ZQG EM 350 A JL 1-318 PDB
7AJU EM 380 A JL 1-318 PDB
7WTL EM 330 A JL 1-318 PDB
7WTM EM 350 A JL 1-318 PDB
8CBJ EM 380 A y 1-318 PDB
AF-P41819-F1 Predicted AlphaFoldDB

1 variants for P41819

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-39983 288 T>I No SGRP

No associated diseases with P41819

2 regional properties for P41819

Type Name Position InterPro Accession
conserved_site Ribosomal RNA adenine methylase transferase, conserved site 60 - 87 IPR020596
domain Ribosomal RNA adenine methylase transferase, N-terminal 44 - 213 IPR020598

Functions

Description
EC Number 2.1.1.183 Methyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

3 GO annotations of molecular function

Name Definition
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.

3 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKAAKKKYS GATSSKQVSA EKHLSSVFKF NTDLGQHILK NPLVAQGIVD KAQIRPSDVV
70 80 90 100 110 120
LEVGPGTGNL TVRILEQAKN VVAVEMDPRM AAELTKRVRG TPVEKKLEIM LGDFMKTELP
130 140 150 160 170 180
YFDICISNTP YQISSPLVFK LINQPRPPRV SILMFQREFA LRLLARPGDS LYCRLSANVQ
190 200 210 220 230 240
MWANVTHIMK VGKNNFRPPP QVESSVVRLE IKNPRPQVDY NEWDGLLRIV FVRKNRTISA
250 260 270 280 290 300
GFKSTTVMDI LEKNYKTFLA MNNEMVDDTK GSMHDVVKEK IDTVLKETDL GDKRAGKCDQ
310
NDFLRLLYAF HQVGIHFS