P41764

PR
Gene name
gsdA (g6pD, AN2981)
Protein name
Glucose-6-phosphate 1-dehydrogenase
Names
G6PD
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN2981.2
EC number
1.1.1.49: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41764

Entry ID Method Resolution Chain Position Source
AF-P41764-F1 Predicted AlphaFoldDB

No variants for P41764

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41764

No associated diseases with P41764

3 regional properties for P41764

Type Name Position InterPro Accession
active_site Glucose-6-phosphate dehydrogenase, active site 193 - 199 IPR019796
domain Glucose-6-phosphate dehydrogenase, NAD-binding 26 - 203 IPR022674
domain Glucose-6-phosphate dehydrogenase, C-terminal 205 - 493 IPR022675

Functions

Description
EC Number 1.1.1.49 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
pentose-phosphate shunt, oxidative branch The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSATIARAEE QQNGSTVELK DDTVIVVLGA SGDLAKKKTF PALFGLFRNK FLPKGIKIVG
70 80 90 100 110 120
YARTQMDHNE YLKRVRSYIK TPTKEIEEQL NSFCELCTYI SGQYDQDDSF KNLAKHLEEI
130 140 150 160 170 180
EKNQKEQNRV FYMALPPSVF ITVSEQLKRN CYPKNGVARI IVEKPFGKDL QSSRDLQKAL
190 200 210 220 230 240
EPNWKEEEIF RIDHYLGKEM VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG
250 260 270 280 290 300
GYFDEFGIIR DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDP IQPKDVIIGQ
310 320 330 340 350 360
YGRSLDGSKP AYKEDDTVPQ DSRCPTFCAL VAHIKNERWD GVPFIMKAGK ALNEQKTEIR
370 380 390 400 410 420
IQFKDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL SMQTVVTELD LTYRRRFSDL
430 440 450 460 470 480
KIPEAYESLI LDALKGDHSN FVRDDELDAS WRMFTPLLHY LDDNKEIIPM EYPYGSRGPS
490 500 510
VLDDFTASYG YKFSDAAGYQ WPLTHTTPNR L