P41557

PR
Gene name
rpo2C
Protein name
DNA-directed RNA polymerase subunit Rpo2C
Names
DNA-directed RNA polymerase subunit B'
Species
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
KEGG Pathway
mvn:Mevan_0672
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41557

Entry ID Method Resolution Chain Position Source
AF-P41557-F1 Predicted AlphaFoldDB

No variants for P41557

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41557

No associated diseases with P41557

8 regional properties for P41557

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 679 - 1065 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 918 - 930 IPR007121
domain RNA polymerase Rpb2, domain 7 1067 - 1141 IPR007641
domain RNA polymerase Rpb2, domain 2 140 - 288 IPR007642-1
domain RNA polymerase Rpb2, domain 2 372 - 414 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 29 - 460 IPR007644
domain RNA polymerase Rpb2, domain 3 473 - 541 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 551 - 618 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKQANVYVN GKLIDTSKDP ENLVKSLRIQ RRSGKLSPNT SISFNEESND IHISTDGGRA
70 80 90 100 110 120
VRPLVVVENG FSKLTNELLE KVNNNELTFE YLVKTGVIEF LDAEEEENAR IAMYNDEITF
130 140 150 160 170 180
ENTHVEIDPL VILGIGAGVA PYPEHNSAPR ITMAAAMGKQ SLGIPMANIK WRMDTRGHLL
190 200 210 220 230 240
HYPQVPLVRT KHQEILGFDK RPAGQNFVVA VMSYEGYNME DAFVINKASL ERGLGRSTFF
250 260 270 280 290 300
RSYESFEKRY PGGQLDKFEV PEKGVRGYRA EEAYRNLGDD GLIDLESEVR SGDVILGKTS
310 320 330 340 350 360
PPRFLEEQEI TLQTKSQRRD TSVTIRHGEE GVVDLVILSE TKEGNRLGKV RVRDLRVPEF
370 380 390 400 410 420
GDKFASRHGQ KGVIGLVVPQ EDLPFTEDGV IPDLIINPHA IPSRMTIGQV LEMIGGKVGS
430 440 450 460 470 480
LECRRVDGTI FSGEGEWALR HALENYGFTH SGKETMYDGK TGRKLECEIF VGVAYYQKLH
490 500 510 520 530 540
HLVAGKIHAR SRGPIQVLTR QPTEGRAREG GLRFGEMERD VLVAHGAALL LKERLLDESD
550 560 570 580 590 600
PHEDYVCAKC GEIAIFDYKR GMKFCPVCGE SEDIQDNRKI PPVKIAYAFK LLLDELKSMG
610
IDPKLKLKDR A