P41554

PR
Gene name
icl
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase
Species
Rhodococcus fascians
KEGG Pathway
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41554

Entry ID Method Resolution Chain Position Source
AF-P41554-F1 Predicted AlphaFoldDB

No variants for P41554

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41554

No associated diseases with P41554

2 regional properties for P41554

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 189 - 194 IPR018523
domain ICL/PEPM domain 56 - 362 IPR039556

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTTGTPKTT AEIQQDWDTN PRWKGVTRNF TAQQVSDLQG TVVEEATLAR RGSEILWDLV
70 80 90 100 110 120
NNEDYINSLG ALTGNQAVQQ IRAGLQAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPSV
130 140 150 160 170 180
VRRINNALLR ADEIAKIEGD TSVKNWVAPI VADAEAGFGG ALNAYELQKA MIVAGAAGVH
190 200 210 220 230 240
WEDQLASEKK CGHLGGKVLI PTQQHIRTLT SARLASDVAD VPSVIIARTD AEAATLITSD
250 260 270 280 290 300
VDERDREFLD GTRTAEGFFG VKNGIEPCIA RAKAYAPYAD LIWMETGVPD LEVAKKFSES
310 320 330 340 350 360
VRSEFPDQLL AYNWSPSFNW KAHLDDATIA KFQKELGAMG FKFQFITLAG FHSLNYGMFD
370 380 390 400 410 420
LAHGYAREGM TAFVDLQERE FKAAEERGFT AIKHQREVGA GYFDRIATTV DPNTSTAALK
GSTEEGQFH