P41513

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Pectobacterium carotovorum (Erwinia carotovora)
KEGG Pathway
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

813-878 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41513

Entry ID Method Resolution Chain Position Source
AF-P41513-F1 Predicted AlphaFoldDB

No variants for P41513

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41513

No associated diseases with P41513

7 regional properties for P41513

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 11 - 509 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 538 - 584 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 588 - 637 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 645 - 687 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 691 - 736 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 742 - 788 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 792 - 838 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMSVLGNDWN
70 80 90 100 110 120
KPYKKSARVV GDVIGKYHPH GDSAVYETIV RMAQPFSLRY MLVDGQGNFG SIDGDSAAAM
130 140 150 160 170 180
RYTEIRMSKI AHELLADLEK ETVDFVPNYD GTEQIPDVMP TRIPNLLVNG SSGIAVGMAT
190 200 210 220 230 240
NIPPHNLTEV VNGCLAYIDD ENISLEGLME HIKGPDFPTA AIINGRRGIE EAYRTGRGKI
250 260 270 280 290 300
YIRARAEVEA DAKTGRETII VHEIPYQVNK ARLIEKIAEL VKDKRIEGIS ALRDESDKDG
310 320 330 340 350 360
MRIVIEIKRD AVGEVVLNNL YSQTQLQTSF GINMVALHQG QPKIMPLKDI LVAFVRHRRE
370 380 390 400 410 420
VVTRRTIFEL RKARDRAHIL EGLAIALANI DPIIELIRRA ASPAEAKASL IAQAWELGSV
430 440 450 460 470 480
ATMLERAGDD AARPEWLEPE FGIRDGRYYL TEQQAQAILD LRLQKLTGME HEKLLDEYKE
490 500 510 520 530 540
LLAEIAELLY ILNSPERLME VIREELEAFK TQYSDERRTE ITANTADINI EDLINQEDVV
550 560 570 580 590 600
VTLSHQGYVK YQPLSDYEAQ RRGGKGKSAA RIKEEDFIDR LLVANTHDTI LCFSSRGRLY
610 620 630 640 650 660
WMKVYQLPEA SRGARGRPIV NLLPLEADER ITAILPVREY EEGRHIFMAT ASGTVKKTAL
670 680 690 700 710 720
TEFSRHVSGI IAVNLNEGDE LIGVDLTDGS DEAMLFSAEG KVVRFSEQAV RSMGRTATGV
730 740 750 760 770 780
RGINLQGEDR VVSLIIPRGE GDILTVTQNG FGKRTAVSEY PTKSRATKGV ISIKVSERNG
790 800 810 820 830 840
KVVGAVQVDA ADQIMMITDA GTLVRTRVSE VSIVGRNTQG VTLIRTAEDE HVVGLQRVAE
850 860 870
PVEDEELDGV VKVEGEVAED DDAIDDIDGD DDIAEDDE