P41443

PR
Gene name
gspH (hofH, hopH, b3329, JW3291)
Protein name
Type II secretion system protein H
Names
T2SS minor pseudopilin H, General secretion pathway protein H, Protein transport protein HofH, Putative general secretion pathway protein H
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3329
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P41443

Entry ID Method Resolution Chain Position Source
2KNQ NMR - A 30-169 PDB
AF-P41443-F1 Predicted AlphaFoldDB

No variants for P41443

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41443

No associated diseases with P41443

2 regional properties for P41443

Type Name Position InterPro Accession
ptm Prokaryotic N-terminal methylation site 1 - 27 IPR012902
domain General secretion pathway, GspH 44 - 143 IPR022346

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
type II protein secretion system complex A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein secretion by the type II secretion system The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNQQRGFTLL EMMLVLALVA ITASVVLFTY GREDVASTRA RETAARFTAA LELAIDRATL
70 80 90 100 110 120
SGQPVGIHFS DSAWRIMVPG KTPSAWRWVP LQEDAADESQ NDWDEELSIH LQPFKPDDSN
130 140 150 160
QPQVVILADG QITPFSLLMA NAGTGEPLLT LVCSGSWPLD QTLARDTRP