P41374
Gene name |
eIF2alpha |
Protein name |
Eukaryotic translation initiation factor 2 subunit 1 |
Names |
Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG9946 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P41374
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P41374-F1 | Predicted | AlphaFoldDB |
No variants for P41374
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P41374 | |||||
No associated diseases with P41374
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 2 complex | Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. |
| eukaryotic translation initiation factor 2B complex | A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. |
| multi-eIF complex | A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosome binding | Binding to a ribosome. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALTSRFYNE | RYPEIEDVVM | VNVLSIAEMG | AYVHLLEYNN | IEGMILLSEL | SRRRIRSINK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIRVGKTEPV | VVIRVDKEKG | YIDLSKRRVS | PEDVEKCTER | FAKAKAINSL | LRHVADILGF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGNEKLEDLY | QKTAWHFEKK | YNNKTVAYDI | FKQSVTDPTV | FDECNLEPET | KEVLLSNIKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLVSPTVKIR | ADIECSCYGY | EGIDAVKASL | TKGLELSTEE | LPIRINLIAP | PLYVMTTSTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKTDGLKALE | VAIEHIRAKT | SEYDGEFKVI | MAPKLVTAID | EADLARRLER | AEAENAQVAG |
| 310 | 320 | 330 | 340 | ||
| DDDEEDGADQ | EGMQFDPEKE | FNHKGSGAGR | ANEEDEEEEE | D |