P41111

PR
Gene name
EIF2B4 (EIF2BD)
Protein name
Translation initiation factor eIF-2B subunit delta
Names
eIF-2B GDP-GTP exchange factor subunit delta
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009560
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41111

Entry ID Method Resolution Chain Position Source
AF-P41111-F1 Predicted AlphaFoldDB

No variants for P41111

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41111

No associated diseases with P41111

No regional properties for P41111

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P41111

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.

1 GO annotations of molecular function

Name Definition
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

6 GO annotations of biological process

Name Definition
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
regulation of catalytic activity Any process that modulates the activity of an enzyme.
T cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAVAVAVRE DSGSGMKAEL SARPGAGGKE MTQEEKLQLR KEKKQQKKKR KEEKGTDVDT
70 80 90 100 110 120
ASAVSAAQCP GPAREAPGPG SQSSTPGEKV PAGRTKAELR AERRAKQEAE RALKQARKGE
130 140 150 160 170 180
QGGPPPQASP STAGEAPAGG KRLTEHTQAD DPTLLRRLVR KSERQQVPTR KDYGSKVSLF
190 200 210 220 230 240
SHLPQYSRQN SLTQYMSIPS SVIHPAMVRL GLQYSQGLIS GSNARCIALL RALQQVIQDY
250 260 270 280 290 300
TTPPNEELSR DLVNKLKPYI CFLTQCRPLS ASMYNAIKFL NKEITGVSST KREEEAKAEL
310 320 330 340 350 360
QAAADRYVQE KIVLAAQAIL RFASKKISNG DVILVYGCSS LVSRILQEAW SEGRKFRVVV
370 380 390 400 410 420
VDSRPRLEGR HMLRFLVRAG VPASYLLIPA ASYVLPEVSK VLLGAHALLA NGSVMSRVGT
430 440 450 460 470 480
AQLALVARAH NVPVLVCCET YKFCERVQTD AFVSNELDDP DDLQCERGDH VALANWQSHP
490 500 510 520
SLRLLNLVYD VTPPELVDLV ITELGMIPCS SVPVVLRVKS SDQ