P40996

PR
Gene name
scd2 (ral3, SPAC22H10.07)
Protein name
Protein scd2/ral3
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC22H10.07
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

60-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40996

Entry ID Method Resolution Chain Position Source
AF-P40996-F1 Predicted AlphaFoldDB

6 variants for P40996

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2384246_C_T 341 T>M No Jeffares_SNPs
I_2384525_C_A 434 S>Y No Jeffares_SNPs
I_2384591_C_T 456 A>V No Jeffares_SNPs
I_2384596_T_A 458 S>T No Jeffares_SNPs
I_2384681_A_G 486 E>G No Jeffares_SNPs
I_2384737_G_A 505 A>T No Jeffares_SNPs

No associated diseases with P40996

9 regional properties for P40996

Type Name Position InterPro Accession
repeat WD40 repeat 330 - 449 IPR001680-1
repeat WD40 repeat 449 - 670 IPR001680-2
domain F-box domain 163 - 210 IPR001810
conserved_site WD40 repeat, conserved site 354 - 368 IPR019775-1
conserved_site WD40 repeat, conserved site 434 - 448 IPR019775-2
conserved_site WD40 repeat, conserved site 475 - 489 IPR019775-3
repeat G-protein beta WD-40 repeat 354 - 368 IPR020472-1
repeat G-protein beta WD-40 repeat 434 - 448 IPR020472-2
repeat G-protein beta WD-40 repeat 614 - 628 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
Cdc42 GTPase complex A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway.
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cortical dynamic polarity patch A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip.

2 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.

7 GO annotations of biological process

Name Definition
cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized.
conjugation with cellular fusion A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
establishment or maintenance of cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.
positive regulation of mating projection assembly Any process that activates or increases the frequency, rate or extent of mating projection assembly.
regulation of conjugation with cellular fusion Any process that modulates the rate or frequency of conjugation with cellular fusion.
regulation of establishment or maintenance of cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape.
regulation of protein localization to cell division site involved in cytokinesis Any regulation of protein localization to cell division site that is involved in cytokinesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKIKRTWKT HSRILDKDPF SIEPPRKVIR ALYDYTARKA TEVSFAKGDF FHVIGRENDK
70 80 90 100 110 120
AWYEVCNPAA GTRGFVPVSH FEEIGKTVKS ERDSDGSGQI SFTDLTTNSS TTRSSISELH
130 140 150 160 170 180
SGSQPLFGIV QFDFAAERPD ELEAKAGEAI IIIARSNHEW LVAKPIGRLG GPGLIPLSFI
190 200 210 220 230 240
QLRDLKTGAV IKDVSEAVLR ISCIPRVEDW KRAAADYKKS SIPLGKFSDG ETQTMPSLSP
250 260 270 280 290 300
STENLQINND VTYQAATDNS STFPGSVANE LTPLQTLESR TASIASKNKK DMSSEPTVVA
310 320 330 340 350 360
AMVENYMIRD DQYWYLVRAV MSDGKHRNLC RYYEDFFNFQ TKFLELFPNE AGRGDERRVI
370 380 390 400 410 420
PYMPGPVDDV NELISSQRAM DLDVYLKEMC RLPARLLENE LVKLFFLPLD GDVESPHPTS
430 440 450 460 470 480
TMPEALPREP LSFSLPEKAP EKATNISIPE SAPTTAGSTC KVKVRLGDET FALRVPSDIS
490 500 510 520 530
FEDFCERLTN KLGECEHLSY RDTNANKVLP LNNVDDLRKA CSQESGVLLF AERRRF