AiPD: Autoinhibited Protein Database

Gene name	HUL4 (YJR036C, J1608)
Protein name	Probable E3 ubiquitin-protein ligase HUL4
Names	HECT ubiquitin ligase 4, HECT-type E3 ubiquitin transferase HUL4
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YJR036C
EC number	2.3.2.26: Aminoacyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-107 (Predicted disordered autoinhibitory region) PR

1-107 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P40985-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s10-503372	5	F>I	No	SGRP
s10-503344	14	G>D	No	SGRP
s10-503345	14	G>S	No	SGRP
s10-503335	17	G>A	No	SGRP
s10-503186	67	S>P	No	SGRP
s10-503096	97	I>V	No	SGRP
s10-503030	119	N>H	No	SGRP
s10-503017	123	S>N	No	SGRP
s10-503014	124	T>M	No	SGRP
s10-502760	209	N>H	No	SGRP
s10-502732	218	S>N	No	SGRP
s10-502379	336	S>P	No	SGRP
s10-502253	378	Q>K	No	SGRP
s10-502169	406	A>T	No	SGRP
s10-502156	410	T>M	No	SGRP
s10-502132	418	T>I	No	SGRP
s10-502132	418	T>S	No	SGRP
s10-501969	472	C>W	No	SGRP
s10-501643	581	N>S	No	SGRP
s10-501347	680	F>L	No	SGRP
s10-501146	747	V>F	No	SGRP
s10-500888	833	A>S	No	SGRP

Type	Name	Position	InterPro Accession
domain	HECT domain	521 - 892	IPR000569

		Description
EC Number	2.3.2.26	Aminoacyltransferases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
prospore membrane	The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.
TRAMP complex	A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control.

Name	Definition
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

Name	Definition
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
RNA fragment catabolic process	The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins