P40971

PR
Gene name
LYS14 (YDR034C, YD9673.04C)
Protein name
Lysine biosynthesis regulatory protein LYS14
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR034C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-278 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40971

Entry ID Method Resolution Chain Position Source
AF-P40971-F1 Predicted AlphaFoldDB

16 variants for P40971

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-512101 2 F>L No SGRP
s04-511812 99 G>S No SGRP
s04-511767 114 Q>E No SGRP
s04-511737 124 A>T No SGRP
s04-511397 237 K>T No SGRP
s04-511391 239 R>Q No SGRP
s04-511382 242 L>S No SGRP
s04-511340 256 G>A No SGRP
s04-511118 330 S>T No SGRP
s04-510551 519 N>S No SGRP
s04-510505 534 D>E No SGRP
s04-510404 568 S>L No SGRP
s04-509960 716 D>A No SGRP
s04-509864 748 K>I No SGRP
s04-509855 751 Y>F No SGRP
s04-509828 760 K>R No SGRP

No associated diseases with P40971

1 regional properties for P40971

Type Name Position InterPro Accession
domain Zn(2)Cys(6) fungal-type DNA-binding domain 153 - 197 IPR001138

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
lysine biosynthetic process The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFESVNLDEN SPEDRELAKV LSPPGSYLSP ASLDSGSSFT NSGTSTSCFE PKNNLPSLSF
70 80 90 100 110 120
LNARAGSLGG IFNHKQMTSP SNSNIGGENV ESTTSSNDGS NENAGHPTTS EQDQNADHPT
130 140 150 160 170 180
ISQADDNGHS SLTPNPAVTS TVTDKKGNTV KRKYSRNGCS ECKRRRMKCD ETKPTCWQCA
190 200 210 220 230 240
RLNRQCVYVL NPKNKKRRTS NAQRVKEFRK HSTSLDNDHN NARKRQHSSC KAEKKKKVRQ
250 260 270 280 290 300
NLSEDTTDPK PITDNGKNVP LDEIESLEIP NLDLTTTMNG YDVNLLMQNL NDMVNMKLHD
310 320 330 340 350 360
SYLLNEELKG LDLPDLDIPE LLPASNVNSS VPISFLVNNV ITFNTKLSSF KLGGIHDKYL
370 380 390 400 410 420
KIFYYDCLDS IAPFFQNQGN PLRDILLSFA KNEAYLLSSI LATGASIAYR KSNNLEDERN
430 440 450 460 470 480
YCAYLSHCLS LLGEQFKNES NVLNRIEPII LTVIMLAWDC IYSMNSQWRS HLKGVTDLFK
490 500 510 520 530 540
KINAGNSSKV LNVAKCWFKV METFASISTV FGGSLIDNND LDAIFDPYDY QYVDSLKFLN
550 560 570 580 590 600
IMTPLNEFNL LRGHKEDFDL VIKEVFKSLN TIRSTEKNYF SKEEGLFTKK LDYLLLSSQT
610 620 630 640 650 660
SSEKSKDQIS YFNTQKILVE IDKQLDYEFI DKSGIIPSDN QSHPRISNIH DNAIDMVTLK
670 680 690 700 710 720
NGEEVAISWY DISHQTQVLS FLLIVLLKLL GMPKESSTIQ QVVKKIMSFF KFLDSDSPPQ
730 740 750 760 770 780
NSRTCYSNFA VLIAGLNAMD EETRAIVKRY YKINGGKFQK LTEHNLNRLE KVWYGKNQNY
RLEEQDVLTW