P40946

SS
Gene name
Arf6 (Arf3, Arf51F, CG8156)
Protein name
ADP-ribosylation factor 6
Names
ARF6 , ADP ribosylation factor at 51F , ADP-ribosylation factor 3
Species
Mus musculus (Mouse)
KEGG Pathway
dme:Dmel_CG8156
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Tyrosine-protein kinase receptor TYRO3 (Tyro3) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of Tyro3.

Autoinhibitory domains (AIDs)

3-16 (N-terminal helix) SS

Target domain

16-138 (Small GTP-binding protein domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40946

Entry ID Method Resolution Chain Position Source
AF-P40946-F1 Predicted AlphaFoldDB

No variants for P40946

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P40946

No associated diseases with P40946

14 regional properties for P40946

Type Name Position InterPro Accession
domain Protein kinase domain 508 - 785 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 509 - 776 IPR001245
domain Immunoglobulin subtype 2 45 - 114 IPR003598-1
domain Immunoglobulin subtype 2 141 - 200 IPR003598-2
domain Immunoglobulin subtype 39 - 126 IPR003599-1
domain Immunoglobulin subtype 135 - 212 IPR003599-2
domain Fibronectin type III 215 - 310 IPR003961-1
domain Fibronectin type III 313 - 406 IPR003961-2
domain Immunoglobulin-like domain 26 - 118 IPR007110-1
domain Immunoglobulin-like domain 129 - 209 IPR007110-2
active_site Tyrosine-protein kinase, active site 641 - 653 IPR008266
domain Immunoglobulin I-set 38 - 122 IPR013098
binding_site Protein kinase, ATP binding site 514 - 540 IPR017441
domain Tyrosine-protein kinase, catalytic domain 508 - 776 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse The part of a synapse that is part of the presynaptic cell.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

3 GO annotations of molecular function

Name Definition
enzyme activator activity Binds to and increases the activity of an enzyme.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction

15 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
behavioral response to ethanol Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
imaginal disc-derived wing morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
male meiosis cytokinesis A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
myoblast fusion A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
protein localization to endosome A process in which a protein is transported to, or maintained in, a location within an endosome.
regulation of dendritic spine development Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
response to alcohol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40994 ARF3 ADP-ribosylation factor 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P26990 ARF6 ADP-ribosylation factor 6 Gallus gallus (Chicken) SS
P40945 Arf4 ADP ribosylation factor 4 Drosophila melanogaster (Fruit fly) SS
P61209 Arf1 ADP-ribosylation factor 1 Drosophila melanogaster (Fruit fly) SS
P62330 ARF6 ADP-ribosylation factor 6 Homo sapiens (Human) EV
P62331 Arf6 ADP-ribosylation factor 6 Mus musculus (Mouse) SS
Q007T5 ARF6 ADP-ribosylation factor 6 Sus scrofa (Pig) SS
P62332 Arf6 ADP-ribosylation factor 6 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MALRRSMGWP GLRPLLLAGL ASLLLPGSAA AGLKLMGAPV KMTVSQGQPV KLNCSVEGME
70 80 90 100 110 120
DPDIHWMKDG TVVQNASQVS ISISEHSWIG LLSLKSVERS DAGLYWCQVK DGEETKISQS
130 140 150 160 170 180
VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IYWWRGLTKV GGPAPSPSVL
190 200 210 220 230 240
NVTGVTQRTE FSCEARNIKG LATSRPAIVR LQAPPAAPFN TTVTTISSYN ASVAWVPGAD
250 260 270 280 290 300
GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG
310 320 330 340 350 360
DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD
370 380 390 400 410 420
ELMVEGTRAN LTDWDPQKDL ILRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWV
430 440 450 460 470 480
PVVLGVLTAL ITAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA RSFNRERPER
490 500 510 520 530 540
IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE DGSFVKVAVK
550 560 570 580 590 600
MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM VILPFMKHGD
610 620 630 640 650 660
LHAFLLASRI GENPFNLPLQ TLVRFMVDIA CGMEYLSSRN FIHRDLAARN CMLAEDMTVC
670 680 690 700 710 720
VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VHSDVWAFGV TMWEIMTRGQ
730 740 750 760 770 780
TPYAGIENAE IYNYLIGGNR LKQPPECMEE VYDLMYQCWS ADPKQRPSFT CLRMELENIL
790 800 810 820 830 840
GHLSVLSTSQ DPLYINIERA EQPTESGSPE VHCGERSSSE AGDGSGVGAV GGIPSDSRYI
850 860 870
FSPGGLSESP GQLEQQPESP LNENQRLLLL QQGLLPHSSC