P40815

PR
Gene name
res
Protein name
Type III restriction-modification enzyme StyLTI Res subunit
Names
Type III R-M system StyLTI, Type III restriction enzyme StyLTI
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM0358
EC number
3.1.21.5: Endodeoxyribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

431-508 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40815

Entry ID Method Resolution Chain Position Source
AF-P40815-F1 Predicted AlphaFoldDB

7 variants for P40815

Variant ID(s) Position Change Description Diseaes Association Provenance
17 A>R strain: LT7 [UniProt] No
293 K>EINPPT strain: LT7 [UniProt] No
350 S>T strain: LT7 [UniProt] No
420 L>V strain: LT7 [UniProt] No
464 S>R strain: LT7 [UniProt] No
536 G>AV strain: LT7 [UniProt] No
945 D>IRLFLMRNVNSSICCVGKISMSSLRKDQRAGGIFYDQWLD strain: LT7 [UniProt] No

No associated diseases with P40815

2 regional properties for P40815

Type Name Position InterPro Accession
domain Helicase/UvrB, N-terminal 7 - 229 IPR006935
domain VRR-NUC domain 874 - 970 IPR014883

Functions

Description
EC Number 3.1.21.5 Endodeoxyribonucleases producing 5'-phosphomonoesters
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
type III site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites.

1 GO annotations of biological process

Name Definition
DNA restriction-modification system A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMNILLEELP HQEQALAAIL ASFTGIDHAQ ADHNHYANPL IKERYDDKAN IDVKMETGTG
70 80 90 100 110 120
KTYVYTRLMY ELHQKYGLFK FVLVVPTPAI KEGARNFITS DYARQHFSQF YENTRMELCT
130 140 150 160 170 180
INAGDFKVKS GRKNFPAQLL SFTDASRRDS HTIQVLLINA QMLNSASMTR DDYDQTLLGG
190 200 210 220 230 240
LTSPVKGLQM TRPVVIIDEP HRFARDNKFY RAIQAIQPQM IVRFGATFPD IVEGKGKNKC
250 260 270 280 290 300
VRKDYYRRQP QFDLNAVDSF NDGLVKGIDI YYPNLPEEQA NNRYIVDSVT AKKLILRRGS
310 320 330 340 350 360
KIAEVGVGEN LADVDAGFEG SIEYAGSKML SNDLELEAGM ALVPGTFGAS YQELIIQDAI
370 380 390 400 410 420
DKHFDTEQAN FLRSNEPENN APRIKTLSLF FIDSIKSYRD DEGWLKVTFE RLLKKKLTQL
430 440 450 460 470 480
IDDYQRKTLP REVEYLSFLQ ATLASLHSDN QNVHAGYFGE DRGSGDEAIQ AEVDDILKNK
490 500 510 520 530 540
EKLLSFSDHH GNWETRRFLF SKWTLREGWD NPNVFVIAKL RSSGSESSKI QEVGRGLRLP
550 560 570 580 590 600
VDENGHRVHQ EEWPSRLSFL IGYDEKAFAS MLVDEINRDS KVQLNEQKLD EAMITLIVTE
610 620 630 640 650 660
RQKVDPAFTE LRLLEDLDDK KLINRSNEFK PSVTLNGETK SGFAWLLEFY PELTQARVRA
670 680 690 700 710 720
DRIRDNKPAS RLRVRLRKEN WEQLSSIWEQ FSRRYMLQFE RSGASLEQIA AEVLRDPALY
730 740 750 760 770 780
IRQKPSQVQQ RLVSNEDNGR FEVAQREGEL AASEFMAGMK YGHFLKQLAL RTSLPVNVLH
790 800 810 820 830 840
PVLMAMLRDV LHGDSRYLSE ISLDNMTRAL QTRINAHFAQ RHDYLPLDFQ ASTSVFDSTA
850 860 870 880 890 900
RQFREEISAE IVGKNVDENA IDDPRSLYQI PPLRYDSVDP ELPLLKYDYP QQVSVFGKLP
910 920 930 940 950 960
KRAIQIPKYT GGSTTPDFVY RIERQDADSV YLLVETKAEN MRVGDQVILD AQRKFFDMLR
970 980
RQNINVEFAE ATSAPAVFST INGLIEGKAN