P40566

PR
Gene name
EGH1
Protein name
Ergosteryl-beta-glucosidase
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIR007W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

569-643 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40566

Entry ID Method Resolution Chain Position Source
AF-P40566-F1 Predicted AlphaFoldDB

15 variants for P40566

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-370902 68 D>N No SGRP
s09-370989 97 A>S No SGRP
s09-371241 181 G>S No SGRP
s09-371338 213 Q>R No SGRP
s09-371569 290 T>M No SGRP
s09-371703 335 S>G No SGRP
s09-371939 413 E>D No SGRP
s09-371949 417 I>L No SGRP
s09-372201 501 A>T No SGRP
s09-372268 523 D>G No SGRP
s09-372331 544 G>E No SGRP
s09-372468 590 T>S No SGRP
s09-372478 593 K>R No SGRP
s09-372587 629 H>Q No SGRP
s09-372675 659 Q>K No SGRP

No associated diseases with P40566

3 regional properties for P40566

Type Name Position InterPro Accession
domain Glycoside hydrolase, family 5 69 - 268 IPR001547
conserved_site Glycoside hydrolase, family 5, conserved site 258 - 267 IPR018087
domain Glycoside hydrolase family 5, C-terminal domain 654 - 736 IPR041036

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Vacuole membrane ; Peripheral membrane protein
  • Localizes in the cytosol until the initial logarithmic phase, then targets to a yet unidentified organelle with a granule structure in the middle logarithmic phase, and finally localizes at the vacuole membranes in the stationary phase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.

2 GO annotations of molecular function

Name Definition
beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
steryl-beta-glucosidase activity Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.

2 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
ergosteryl 3-beta-D-glucoside catabolic process The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPAKIHISAD GQFCDKDGNE IQLRGVNLDP SVKIPAKPFL STHAPIENDT FFEDADKVSF
70 80 90 100 110 120
INHPLVLDDI EQHIIRLKSL GYNTIRLPFT WESLEHAGPG QYDFDYMDYI VEVLTRINSV
130 140 150 160 170 180
QQGMYIYLDP HQDVWSRFSG GSGAPLWTLY CAGFQPANFL ATDAAILHNY YIDPKTGREV
190 200 210 220 230 240
GKDEESYPKM VWPTNYFKLA CQTMFTLFFG GKQYAPKCTI NGENIQDYLQ GRFNDAIMTL
250 260 270 280 290 300
CARIKEKAPE LFESNCIIGL ESMNEPNCGY IGETNLDVIP KERNLKLGKT PTAFQSFMLG
310 320 330 340 350 360
EGIECTIDQY KRTFFGFSKG KPCTINPKGK KAWLSAEERD AIDAKYNWER NPEWKPDTCI
370 380 390 400 410 420
WKLHGVWEIQ NGKRPVLLKP NYFSQPDATV FINNHFVDYY TGIYNKFREF DQELFIIIQP
430 440 450 460 470 480
PVMKPPPNLQ NSKILDNRTI CACHFYDGMT LMYKTWNKRI GIDTYGLVNK KYSNPAFAVV
490 500 510 520 530 540
LGENNIRKCI RKQLSEMQKD AKSMLGKKVP VFFTEIGIPF DMDDKKAYIT NDYSSQTAAL
550 560 570 580 590 600
DALGFALEGS NLSYTLWCYC SINSHIWGDN WNNEDFSIWS PDDKPLYHDT RAKTPTPEPS
610 620 630 640 650 660
PASTVASVST STSKSGSSQP PSFIKPDNHL DLDSPSCTLK SDLSGFRALD AIMRPFPIQI
670 680 690 700 710 720
HGRFEFAEFN LCNKSYLLKL VGKTTPEQIT VPTYIFIPRH HFTPSRLSIR SSSGHYTYNT
730 740 750 760
DYQVLEWFHE PGHQFIEICA KSKSRPNTPG SDTSNDLPAE CVIS