P40558

PR
Gene name
CFD1
Protein name
Cytosolic Fe-S cluster assembly factor CFD1
Names
Cytosolic Fe-S cluster-deficient protein 1, Ribosomal export protein 19
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL003W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40558

Entry ID Method Resolution Chain Position Source
AF-P40558-F1 Predicted AlphaFoldDB

5 variants for P40558

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-349152 12 S>T No SGRP
s09-349396 93 S>N No SGRP
s09-349852 245 V>G No SGRP
s09-349956 280 V>I No SGRP
s09-349960 281 V>E No SGRP

No associated diseases with P40558

9 regional properties for P40558

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 423 - 646 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1212 - 1445 IPR003439-2
domain AAA+ ATPase domain 450 - 640 IPR003593-1
domain AAA+ ATPase domain 1238 - 1420 IPR003593-2
domain ABC transporter type 1, transmembrane domain 82 - 350 IPR011527-1
domain ABC transporter type 1, transmembrane domain 861 - 1159 IPR011527-2
conserved_site ABC transporter-like, conserved site 548 - 562 IPR017871
domain CFTR regulator domain 639 - 850 IPR025837
domain Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 389 - 670 IPR047082

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
iron-sulfur cluster assembly complex A protein complex capable of assembling an iron-sulfur (Fe-S) cluster.
Nbp35-Cfd1 ATPase complex An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent FeS chaperone activity Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.
iron-sulfur cluster binding Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEQEIGVPA ASLAGIKHII LILSGKGGVG KSSVTTQTAL TLCSMGFKVG VLDIDLTGPS
70 80 90 100 110 120
LPRMFGLENE SIYQGPEGWQ PVKVETNSTG SLSVISLGFL LGDRGNSVIW RGPKKTSMIK
130 140 150 160 170 180
QFISDVAWGE LDYLLIDTPP GTSDEHISIA EELRYSKPDG GIVVTTPQSV ATADVKKEIN
190 200 210 220 230 240
FCKKVDLKIL GIIENMSGFV CPHCAECTNI FSSGGGKRLS EQFSVPYLGN VPIDPKFVEM
250 260 270 280 290
IENQVSSKKT LVEMYRESSL CPIFEEIMKK LRKQDTTTPV VDKHEQPQIE SPK