P40546

PR
Gene name
FAF1 (YIL019W)
Protein name
Protein FAF1
Names
Forty S assembly factor
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL019W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-176 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for P40546

Entry ID Method Resolution Chain Position Source
4QMF X-ray 280 A A/C 145-220 PDB
5WLC EM 380 A NE 1-346 PDB
6KE6 EM 340 A RV 1-346 PDB
6LQP EM 320 A RV 1-346 PDB
6LQQ EM 410 A RV 1-346 PDB
6LQU EM 370 A RV 1-346 PDB
6ZQA EM 440 A JN 1-346 PDB
6ZQB EM 390 A JN 1-346 PDB
6ZQC EM 380 A JN 1-346 PDB
7AJT EM 460 A JN 1-346 PDB
7SUK EM 399 A NE 91-330 PDB
AF-P40546-F1 Predicted AlphaFoldDB

9 variants for P40546

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-315097 3 L>I No SGRP
s09-315161 24 G>E No SGRP
s09-315259 57 H>D No SGRP
s09-315281 64 G>V No SGRP
s09-315404 105 V>D No SGRP
s09-315596 169 N>S No SGRP
s09-315628 180 V>I No SGRP
s09-315829 247 V>L No SGRP
s09-315967 293 A>T No SGRP

No associated diseases with P40546

11 regional properties for P40546

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 345 - 358 IPR000943-1
domain RNA polymerase sigma-70 369 - 377 IPR000943-2
domain RNA polymerase sigma-70 493 - 505 IPR000943-3
domain RNA polymerase sigma-70 514 - 540 IPR000943-4
domain RNA polymerase sigma factor 70, region 1.1 19 - 87 IPR007127
domain RNA polymerase sigma-70 region 3 400 - 476 IPR007624
domain RNA polymerase sigma-70 region 2 321 - 390 IPR007627
domain RNA polymerase sigma-70 region 4 489 - 542 IPR007630
domain RNA polymerase sigma-70 region 1.2 101 - 130 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 317 - 553 IPR012760
domain RNA polymerase sigma-70 like domain 317 - 542 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTLDDDDYIK QMELQRKAFE SQFGSLESMG FEDKTKNIRT EVDTRDSSGD EIDNSDHGSD
70 80 90 100 110 120
FKDGTIESSN SSDEDSGNET AEENNQDSKP KTQPKVIRFN GPSDVYVPPS KKTQKLLRSG
130 140 150 160 170 180
KTLTQINKKL ESTEAKEEKE DETLEAENLQ NDLELQQFLR ESHLLSAFNN GGSGSTNSGV
190 200 210 220 230 240
SLTLQSMGGG NDDGIVYQDD QVIGKARSRT LEMRLNRLSR VNGHQDKINK LEKVPMHIRR
250 260 270 280 290 300
GMIDKHVKRI KKYEQEAAEG GIVLSKVKKG QFRKIESTYK KDIERRIGGS IKARDKEKAT
310 320 330 340
KRERGLKISS VGRSTRNGLI VSKRDIARIS GGERSGKFNG KKKSRR