P40512

PR
Gene name
PCI8 (CSN11, YIH1, YIL071C)
Protein name
Cop9 signalosome complex subunit 11
Names
Proteasome-COP9 signalosome-eIF3 domain protein 8
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL071C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

385-444 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40512

Entry ID Method Resolution Chain Position Source
AF-P40512-F1 Predicted AlphaFoldDB

8 variants for P40512

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-229835 53 L>M No SGRP
s09-229514 160 S>G No SGRP
s09-229317 225 I>M No SGRP
s09-229295 233 L>F No SGRP
s09-229148 282 E>K No SGRP
s09-228788 402 P>S No SGRP
s09-228775 406 S>N No SGRP
s09-228769 408 G>V No SGRP

No associated diseases with P40512

1 regional properties for P40512

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 195 - 387 IPR000717

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFHGAKGPLL IERIGHLLSI NYGEKEERKR WAMQGISYLQ EVQCTSTPYL EILVEESGLR
70 80 90 100 110 120
PVSLLNSQLV GKPHFSLLGG FDENIARDII SHNFQNAIFQ MESEEVPLTK RYQHLEKITQ
130 140 150 160 170 180
ISLLCKNFKG IEEIEYNVKN IIQGRKNFDM LNSMEKDRIS HEVVQDDSFS LLRIQMLLCV
190 200 210 220 230 240
SYFLQERYFD CCTKFFTMMT SEPLTLKVLS EHLDCMNFIS KEEFIMMVNI SVLISIPLDN
250 260 270 280 290 300
YDDFIYLSDL KQFFQMTPLL VNCLELLINT NFNKFFKIWH GEINKICMES LFLEPSWSSS
310 320 330 340 350 360
AAVIMRCKIY FFYLRISKKL QFSYLSSTLG IDLEDIKEEL TKLIISGQLN FEIDGDVIHF
370 380 390 400 410 420
EDSSILQSIV NEISRNGTMI NEVIDKLKNE NTDLKDIIQG NPLMYSGGNN TATIINNESS
430 440
DDMDIDEVND RSDISDSEGG LFEC