P40510

PR
Gene name
SER33 (YIL074C)
Protein name
D-3-phosphoglycerate dehydrogenase 2
Names
3-PGDH 2, 2-oxoglutarate reductase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL074C
EC number
1.1.1.95: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40510

Entry ID Method Resolution Chain Position Source
AF-P40510-F1 Predicted AlphaFoldDB

4 variants for P40510

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-222376 38 L>V No SGRP
s09-222308 60 N>K No SGRP
s09-222228 87 S>F No SGRP
s09-221471 339 L>F No SGRP

No associated diseases with P40510

6 regional properties for P40510

Type Name Position InterPro Accession
domain ACT domain 399 - 469 IPR002912
domain D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 61 - 381 IPR006139
domain D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain 165 - 349 IPR006140
conserved_site D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 201 - 228 IPR029752
conserved_site D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 247 - 269 IPR029753-1
conserved_site D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 276 - 292 IPR029753-2

Functions

Description
EC Number 1.1.1.95 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
alpha-ketoglutarate reductase activity Catalysis of the reaction: 2-oxoglutarate + reduced acceptor = (S)-2-hydroxyglutarate + acceptor.
glyoxylate reductase (NADP+) activity Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.
hydroxypyruvate reductase activity Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+.
identical protein binding Binding to an identical protein or proteins.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.

2 GO annotations of biological process

Name Definition
L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
serine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYSAADNLQ DSFQRAMNFS GSPGAVSTSP TQSFMNTLPR RVSITKQPKA LKPFSTGDMN
70 80 90 100 110 120
ILLLENVNAT AIKIFKDQGY QVEFHKSSLP EDELIEKIKD VHAIGIRSKT RLTEKILQHA
130 140 150 160 170 180
RNLVCIGCFC IGTNQVDLKY AASKGIAVFN SPFSNSRSVA ELVIGEIISL ARQLGDRSIE
190 200 210 220 230 240
LHTGTWNKVA ARCWEVRGKT LGIIGYGHIG SQLSVLAEAM GLHVLYYDIV TIMALGTARQ
250 260 270 280 290 300
VSTLDELLNK SDFVTLHVPA TPETEKMLSA PQFAAMKDGA YVINASRGTV VDIPSLIQAV
310 320 330 340 350 360
KANKIAGAAL DVYPHEPAKN GEGSFNDELN SWTSELVSLP NIILTPHIGG STEEAQSSIG
370 380 390 400 410 420
IEVATALSKY INEGNSVGSV NFPEVSLKSL DYDQENTVRV LYIHRNVPGV LKTVNDILSD
430 440 450 460
HNIEKQFSDS HGEIAYLMAD ISSVNQSEIK DIYEKLNQTS AKVSIRLLY