P40471

PR
Gene name
AYR1
Protein name
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase
Names
ADR, 1-acyl DHAP reductase, Acyl/alkyl DHAP reductase, Acylglycerone-phosphate reductase, Triacylglycerol lipase AYR1, TAG lipase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL124W
EC number
1.1.1.101: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

184-297 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40471

Entry ID Method Resolution Chain Position Source
AF-P40471-F1 Predicted AlphaFoldDB

3 variants for P40471

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-126358 52 Q>R No SGRP
s09-126375 58 I>V No SGRP
s09-126453 84 D>H No SGRP

No associated diseases with P40471

1 regional properties for P40471

Type Name Position InterPro Accession
conserved_site Short-chain dehydrogenase/reductase, conserved site 144 - 172 IPR020904

Functions

Description
EC Number 1.1.1.101 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Lipid droplet
  • Mitochondrion outer membrane
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
1-acyl dihydroxyacetone phosphate reductase activity Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP.
acylglycerone-phosphate reductase activity Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+).
triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

2 GO annotations of biological process

Name Definition
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
triglyceride catabolic process The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSELQSQPKK IAVVTGASGG IGYEVTKELA RNGYLVYACA RRLEPMAQLA IQFGNDSIKP
70 80 90 100 110 120
YKLDISKPEE IVTFSGFLRA NLPDGKLDLL YNNAGQSCTF PALDATDAAV EQCFKVNVFG
130 140 150 160 170 180
HINMCRELSE FLIKAKGTIV FTGSLAGVVS FPFGSIYSAS KAAIHQYARG LHLEMKPFNV
190 200 210 220 230 240
RVINAITGGV ATDIADKRPL PETSIYNFPE GREAFNSRKT MAKDNKPMPA DAYAKQLVKD
250 260 270 280 290
ILSTSDPVDV YRGTFANIMR FVMIFVPYWL LEKGLSKKFK LDKVNNALKS KQKNKDD