P40418

PR
Gene name
SWI6 (KLLA0C01826g)
Protein name
Regulatory protein SWI6
Names
Cell-cycle box factor subunit SWI6, MBF subunit P90, Trans-acting activator of HO endonuclease gene
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_C01826g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-184 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40418

Entry ID Method Resolution Chain Position Source
AF-P40418-F1 Predicted AlphaFoldDB

No variants for P40418

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P40418

No associated diseases with P40418

3 regional properties for P40418

Type Name Position InterPro Accession
repeat Ankyrin repeat 286 - 318 IPR002110-1
repeat Ankyrin repeat 416 - 461 IPR002110-2
domain Swi6, N-terminal 13 - 90 IPR040822

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
MBF transcription complex A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.
SBF transcription complex A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

3 GO annotations of biological process

Name Definition
positive regulation of reciprocal meiotic recombination Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
positive regulation of transcription from RNA polymerase II promoter in response to heat stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
positive regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRPIFKVHK GDRITFQQRL QDGYVCLDQF IPLLTNLSSF NFHRDDPLVE NLDDMVTSQF
70 80 90 100 110 120
NILIDTDRSG TRWITLQKAH ELWDLLQIKD DSGSENLTDH DDDNEANHNG VEDDGQKTPE
130 140 150 160 170 180
NNGRKTDNHT MENGGTENTN NGNNSSNKND GNVTAEGSNF RPATITNGTT SRISGGEPDT
190 200 210 220 230 240
VKHELLDLPD SPTKRHQTKS VSKIPVFQHD LPTVSTLQKT LPPVSNYSND ERAKLETLLQ
250 260 270 280 290 300
RILFPETTNL NVAEGYPSVS LTQQVQELDT QFPNVPLNFN IPIDEHGNTS LHWLCSIANL
310 320 330 340 350 360
DLLKQLIVFG SDRRIGDKSG ESVLVKSVKS VNNYDSGTFE ILLDYLYPCI VMVDDMDRTV
370 380 390 400 410 420
LHHIVITSGM PGCNAAAKYY LDILMGWIVK KQSRTKESHC VLLEDIDLQW VITHLLNARD
430 440 450 460 470 480
SNGDTCLNIA ARLGNVAIVE ALLDYGADPN IANNSGLCPV DFGAGTQPRF QSNTKNLMAT
490 500 510 520 530 540
PTKTHETSLD PMAESTSLIT NIKSLLSKIS NDYGDEIKQH NGKMKELLDT LNIKREALAN
550 560 570 580 590 600
ARDRLAKAKQ IQDEYNLLSD RLNNVENTIA EEDQNFQLAS RELGLSLDDV QEEGLNSADI
610 620 630 640 650 660
AFDADEPFRI SYVYTKFEEK IKDEYNNDFE LFLKHCNLSQ LVHEIYDNFP SRAEIPHPKI
670 680 690 700 710 720
LKARIKAYNR NELHLDSTLQ TIIPHPKILK ARIKAYNRNE LHLDSTLQTI KDKQKNLESK
730 740 750 760
FRKVLSLCLK IDEEKVDSML DGLLQAISNE DPEDIDTDEV NNFLESAAE