P40387
Gene name |
tps1 |
Protein name |
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] |
Names |
Trehalose-6-phosphate synthase, UDP-glucose-glucosephosphate glucosyltransferase |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC328.03 |
EC number |
2.4.1.15: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P40387
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P40387-F1 | Predicted | AlphaFoldDB |
3 variants for P40387
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_3480658_A_T | 449 | M>L | No | Jeffares_SNPs | |
| I_3480748_G_A | 479 | G>S | No | Jeffares_SNPs | |
| I_3480845_C_A | 511 | S>Y | No | Jeffares_SNPs |
No associated diseases with P40387
No regional properties for P40387
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P40387 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.15 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity | Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| ascospore formation | The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota). |
| cellular response to heat | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| trehalose biosynthetic process | The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. |
| trehalose catabolic process | The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. |
| trehalose metabolism in response to stress | The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDAHDTIKS | LTGDASNSRR | LIVVSNRLPI | TIKRKDNGTY | DFSMSSGGLV | SALSGLKKLM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TFQWLGWCGQ | EIPEDEKPMI | IQRLQDECSA | IPVFLDDETA | DRHYNGFSNS | ILWPLFHYHP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEINFDEENW | EAYRAANYAF | AEAIVKNLQD | GDLIWVQDYH | LMVLPQMLRE | LIGDKFKDIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IGFFLHTPFP | SSEIYRVLPV | RNEILEGVLN | CDLVGFHTYD | YARHFLSACS | RILNLSTLPN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVEYNGQMVS | VGTFPIGIDP | EKFSDALKSD | VVKDRIASIE | RRLQGVKVIV | GVDRLDYIKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VPQKFHAFEV | FLEQYPEWVG | KVVLVQVAVP | SRQDVEEYQN | LRAVVNELVG | RINGRFGTVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YTPIHFLHKS | VRFEELVALY | NVSDVCLITS | TRDGMNLVSY | EYICTQQERH | GALILSEFAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AAQSLNGSIV | INPWNTEELA | NSIHDALTMP | EKQREANENK | LFRYVNKYTS | QFWGQSFVGE |
| 490 | 500 | 510 | |||
| LQRIQHYSHP | HPRRTNPILR | TKSAQVLSMN | SSS |