P40376

PR
Gene name
pka1 (tpk, SPBC106.10)
Protein name
cAMP-dependent protein kinase catalytic subunit
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC106.10
EC number
2.7.11.11: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-219 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

341-362 (Activation loop from InterPro)

Target domain

201-456 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P40376

Entry ID Method Resolution Chain Position Source
AF-P40376-F1 Predicted AlphaFoldDB

No variants for P40376

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P40376

No associated diseases with P40376

4 regional properties for P40376

Type Name Position InterPro Accession
domain Cryptochrome/DNA photolyase, FAD-binding domain 241 - 395 IPR005101
domain DNA photolyase, N-terminal 2 - 153 IPR006050
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 290 - 302 IPR018394-1
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 310 - 329 IPR018394-2

Functions

Description
EC Number 2.7.11.11 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cAMP-dependent protein kinase activity cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by glucose binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
negative regulation of cytoplasmic translation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.
negative regulation of gluconeogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
negative regulation of induction of conjugation with cellular fusion Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion.
negative regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.
positive regulation of microtubule depolymerization Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.
positive regulation of protein export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
protein kinase A signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDTTAVASKG STNVGSSTDT LSTSASLHPS MNAGSVNEYS EQQRHGTNSF NGKPSVHDSV
70 80 90 100 110 120
GSDASVSNGH NNHNESSLWT SGIPKALEEA TKSKKPDSLV STSTSGCASA HSVGYQNIDN
130 140 150 160 170 180
LIPSPLPESA SRSSSQSSHQ RHSRDGRGEL GSEHGERRSA MDGLRDRHIR KVRVSQLLDL
190 200 210 220 230 240
QRRRIRPADH TTKDRYGIQD FNFLQTLGTG SFGRVHLVQS NHNRLYYAIK VLEKKKIVDM
250 260 270 280 290 300
KQIEHTCDER YILSRVQHPF ITILWGTFQD AKNLFMVMDF AEGGELFSLL RKCHRFPEKV
310 320 330 340 350 360
AKFYAAEVIL ALDYLHHNQI VYRDLKPENL LLDRFGHLKI VDFGFAKRVS TSNCCTLCGT
370 380 390 400 410 420
PDYLAPEIIS LKPYNKAADW WSLGILIFEM LAGYPPFYSE NPMKLYENIL EGKVNYPSYF
430 440 450 460 470 480
SPASIDLLSH LLQRDITCRY GNLKDGSMDI IMHPWFRDIS WDKILTRKIE VPYVPPIQAG
490 500 510
MGDSSQFDAY ADVATDYGTS EDPEFTSIFK DF