P40360

PR
Gene name
ARG2
Protein name
Amino-acid acetyltransferase, mitochondrial
Names
Arginine-requiring protein 2, Glutamate N-acetyltransferase, N-acetylglutamate synthase, AGS, NAGS
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL071W
EC number
2.3.1.1: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

189-267 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40360

Entry ID Method Resolution Chain Position Source
AF-P40360-F1 Predicted AlphaFoldDB

14 variants for P40360

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-306152 9 E>G No SGRP
s10-306265 47 S>G No SGRP
s10-306475 117 L>F No SGRP
s10-306499 125 R>S No SGRP
s10-306550 142 I>V No SGRP
s10-306656 177 C>Y No SGRP
s10-306994 290 A>T No SGRP
s10-307007 294 S>L No SGRP
s10-307099 325 I>V No SGRP
s10-307195 357 V>M No SGRP
s10-307282 386 K>E No SGRP
s10-307294 390 P>S No SGRP
s10-307319 398 S>N No SGRP
s10-307787 554 R>K No SGRP

No associated diseases with P40360

1 regional properties for P40360

Type Name Position InterPro Accession
domain Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain 365 - 563 IPR006855

Functions

Description
EC Number 2.3.1.1 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
NAGS/NAGK complex A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate.

2 GO annotations of molecular function

Name Definition
acetyl-CoA:L-glutamate N-acetyltransferase activity Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+).
methione N-acyltransferase activity Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+.

2 GO annotations of biological process

Name Definition
arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
ornithine biosynthetic process The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MWRRIFAHEL KYDQPNASSK NLILSVLNTT ATKREAKDYL SKYTNDSGQH NHCLFFIRDL
70 80 90 100 110 120
HKVAPAILSQ FSSVIKRLGM LGLRPMFVIP PSPTHVNIQA ELLDSIVTEA DLKPLHLKEG
130 140 150 160 170 180
LTKSRTGLYH SVFSQESRFF DIGNSNFIPI VKPYVYNEET ASEFMTKDVV KFMDCLCQGN
190 200 210 220 230 240
IPHIDKFFIL NNAGGIPSGE RNDNAHVFIN LSQELEHLSS SLSHNISTLT KREPRSQNLL
250 260 270 280 290 300
HRMEVYVKKD EISSLECEYH DHLENLLLMD KVLSNLAATA TGLITTVKAA ALSSDRKNPL
310 320 330 340 350 360
VYNLLTDRSL ISSSLPRFKK KDGEIDSPAN MFDDHAWYEL PSQQVNAAPS NSDAVLVTTV
370 380 390 400 410 420
LKKGVHIKTY DYKTLTQFNS IGLPKKFHVP EKGAKPSSNS PKLDINKFKS IIDQSFKRSL
430 440 450 460 470 480
DLHDYIKRIN GKIATIIVIG DYEGIAILTY EGSEENSFVY LDKFAVLPHL KGSLGISDII
490 500 510 520 530 540
FNLMFKKFPN EILWRSRKDN VVNKWYFQRS VAVLDLSIDL DPEHCDEKQS QFKLFYYGNP
550 560 570
QYAKRALRDK KRLREFMRSV RDIKPSWENE KNIS