P40350

PR
Gene name
ALG5
Protein name
Dolichyl-phosphate beta-glucosyltransferase
Names
DolP-glucosyltransferase, Asparagine-linked glycosylation protein 5
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL227C
EC number
2.4.1.117: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40350

Entry ID Method Resolution Chain Position Source
AF-P40350-F1 Predicted AlphaFoldDB

10 variants for P40350

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-121160 3 A>E No SGRP
s16-121136 11 R>K No SGRP
s16-120747 141 I>V No SGRP
s16-120678 164 K>E No SGRP
s16-120662 169 A>V No SGRP
s16-120608 187 I>T No SGRP
s16-120386 261 K>R No SGRP
s16-120370 266 L>F No SGRP
s16-120257 304 A>V No SGRP
s16-120177 331 N>D No SGRP

No associated diseases with P40350

1 regional properties for P40350

Type Name Position InterPro Accession
domain Glycosyl transferase, family 1 257 - 427 IPR001296

Functions

Description
EC Number 2.4.1.117 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
  • Its interaction with the substrate UDP-glucose may occur at the cytoplasmic side of the ER, whereas the steps utilizing dolichyl beta-D-glucosyl phosphate take place in the lumen of the ER
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.

1 GO annotations of biological process

Name Definition
protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRALRFLIEN RNTVFFTLLV ALVLSLYLLV YLFSHTPRPP YPEELKYIAI DEKGHEVSRA
70 80 90 100 110 120
LPNLNEHQDD EEIFLSVVIP SYNETGRILL MLTDAISFLK EKYGSRWEIV IVDDGSTDNT
130 140 150 160 170 180
TQYCLKICKE QFKLNYEQFR IIKFSQNRGK GGAVRQGFLH IRGKYGLFAD ADGASKFSDV
190 200 210 220 230 240
EKLIDAISKI ETSSTDLKTT KPAVAIGSRA HMVNTEAVIK RSMIRNCLMY GFHTLVFIFG
250 260 270 280 290 300
IRSIKDTQCG FKLFNRAAIL KIFPYLHTEG WIFDVEILIL AIRKRIQIEE IPISWHEVDG
310 320 330
SKMALAIDSI KMAKDLVIIR MAYLLGIYRD NKKC