P40319

PR
Gene name
ELO3
Protein name
Elongation of fatty acids protein 3
Names
3-keto acyl-CoA synthase ELO3, Affecting plasma membrane ATPase activity protein 1, Suppressor of RAD3 essential function protein 1, Suppressor of Rvs161 and Rvs167 mutations protein 4, Very-long-chain 3-oxoacyl-CoA synthase 3, v-SNARE bypass mutant gene 1 protein
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR372W
EC number
2.3.1.199: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

278-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40319

Entry ID Method Resolution Chain Position Source
AF-P40319-F1 Predicted AlphaFoldDB

5 variants for P40319

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-867396 15 Q>R No SGRP
s12-867404 18 S>P No SGRP
s12-867840 163 T>I No SGRP
s12-868275 308 K>R No SGRP
s12-868296 315 V>A No SGRP

No associated diseases with P40319

1 regional properties for P40319

Type Name Position InterPro Accession
conserved_site ELO family, conserved site 181 - 189 IPR030457

Functions

Description
EC Number 2.3.1.199 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
3-oxo-arachidoyl-CoA synthase activity Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A.
3-oxo-lignoceronyl-CoA synthase activity Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A.
fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C).
very-long-chain 3-ketoacyl-CoA synthase activity Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA.

9 GO annotations of biological process

Name Definition
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
fatty acid elongation The elongation of a fatty acid chain by the sequential addition of two-carbon units.
fatty acid elongation, monounsaturated fatty acid Elongation of a fatty acid chain into which one C-C double bond has been introduced.
fatty acid elongation, polyunsaturated fatty acid Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced.
fatty acid elongation, saturated fatty acid Elongation of a saturated fatty acid chain.
late endosome to vacuole transport via multivesicular body sorting pathway The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.
post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
very long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNTTTSTVIA AVADQFQSLN SSSSCFLKVH VPSIENPFGI ELWPIFSKVF EYFSGYPAEQ
70 80 90 100 110 120
FEFIHNKTFL ANGYHAVSII IVYYIIIFGG QAILRALNAS PLKFKLLFEI HNLFLTSISL
130 140 150 160 170 180
VLWLLMLEQL VPMVYHNGLF WSICSKEAFA PKLVTLYYLN YLTKFVELID TVFLVLRRKK
190 200 210 220 230 240
LLFLHTYHHG ATALLCYTQL IGRTSVEWVV ILLNLGVHVI MYWYYFLSSC GIRVWWKQWV
250 260 270 280 290 300
TRFQIIQFLI DLVFVYFATY TFYAHKYLDG ILPNKGTCYG TQAAAAYGYL ILTSYLLLFI
310 320 330 340
SFYIQSYKKG GKKTVKKESE VSGSVASGSS TGVKTSNTKV SSRKA